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Proteases in intestinal health and disease

In this Review, Deraison and Vergnolle describe the role of extracellular proteases and protease inhibitors in gastrointestinal physiology and in diseases including inflammatory bowel disease, irritable bowel syndrome and colorectal cancer. They also explore emerging therapeutic options for restoring proteolytic balance.

Celine Deraison
Nathalie Vergnolle
Reviews20 Oct 2025
Nature Reviews Gastroenterology & Hepatology

Volume: 23, P: 6-28
Active thrombin produced by the intestinal epithelium controls mucosal biofilms

The roles played by thrombin in the human intestinal mucosa are unclear. Here, the authors show that the commensal microbiota modulates epithelial production of active thrombin, which controls biofilm growth and contributes to protection of the mucosa from bacterial invasion.

Jean-Paul Motta
Alexandre Denadai-Souza
Nathalie Vergnolle
ResearchOpen Access19 Jul 2019
Nature Communications

Volume: 10, P: 1-12
Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2

Gluten triggers celiac disease in genetically predisposed individuals, but additional unknown mechanisms are required. Here, the authors show that proteases from Pseudomonas aeruginosa can modulate inflammatory pathways that are relevant to the development of food sensitivities, independently of the trigger antigen.

Alberto Caminero
Justin L. McCarville
Elena F. Verdu
ResearchOpen Access13 Mar 2019
Nature Communications

Volume: 10, P: 1-14
Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity

Pascal Descargues
Céline Deraison
Alain Hovnanian
Research26 Dec 2004
Nature Genetics

Volume: 37, P: 56-65
Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation

Jean-Paul Motta
Corinne Rolland
Céline Deraison
ResearchOpen Access05 Mar 2021
Mucosal Immunology

Volume: 14, P: 667-678
Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease

Alexandre Denadai-Souza
Chrystelle Bonnart
Céline Deraison
ResearchOpen Access18 May 2018
Scientific Reports

Volume: 8, P: 1-9
Pathogenicity of commensal gut biofilm in prefrail aging

Guillaume Le Cosquer
Melissa Pannier
Jean-Paul Motta
ResearchOpen Access22 May 2025
npj Biofilms and Microbiomes

Volume: 11, P: 1-12
Gastrointestinal biofilms in health and disease

In this Review, Motta, Vergnolle and colleagues describe the organization of microorganisms into planktonic, biofilm and biofilm-dispersed forms in the gastrointestinal tract. The role of the host–biofilm relationship in gut homeostasis and disease is discussed.

Jean-Paul Motta
John L. Wallace
Nathalie Vergnolle
Reviews28 Jan 2021
Nature Reviews Gastroenterology & Hepatology

Volume: 18, P: 314-334

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Proteases in intestinal health and disease

Active thrombin produced by the intestinal epithelium controls mucosal biofilms

Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2

Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity

Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation

Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease

Pathogenicity of commensal gut biofilm in prefrail aging

Gastrointestinal biofilms in health and disease

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