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  • Sakari Kauppinen and colleagues report a method for silencing miRNA families in vivo. They find that seed-targeting 8-mer LNA oligonucleotides, termed tiny LNAs, can lead to long-term miRNA silencing in normal tissues and breast tumors in mice.

    • Susanna Obad
    • Camila O dos Santos
    • Sakari Kauppinen
    Research
    Nature Genetics
    Volume: 43, P: 371-378