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Tumour angiogenesis regulation by the miR-200 family

The microRNA-200 family members have a role in regulating tumour angiogenesis but the underlying mechanism is unclear. In this study, Pecot et al.demonstrate that miR-200 affects angiogenesis by altering endothelial and cancer cell cytokine secretion.

Chad V. Pecot
Rajesha Rupaimoole
Anil K. Sood
Research10 Sept 2013
Nature Communications

Volume: 4, P: 1-14
Snord67 promotes breast cancer metastasis by guiding U6 modification and modulating the splicing landscape

The functions of small nucleolar RNAs (snoRNAs) in cancer remain to be studied. Here the authors show that the snoRNA Snord67 promotes lymph node metastasis of breast cancer cells through guiding modifications of the spliceosome and regulating the splicing landscape.

Yvonne L. Chao
Katherine I. Zhou
Chad V. Pecot
ResearchOpen Access02 May 2025
Nature Communications

Volume: 16, P: 1-23
Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes

The prognosis of cancer patients with lymph node (LN) metastasis is worse than those without. Here, the authors report that while histone deacetylase 11 (HDAC11) inhibition suppresses tumor growth within the LN, it also promotes cancer cell migration out of the LN to form distant metastasis, and therefore suggest caution with HDAC inhibitors.

Patrick L. Leslie
Yvonne L. Chao
Chad V. Pecot
ResearchOpen Access13 Sept 2019
Nature Communications

Volume: 10, P: 1-12
CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

Alterations in the tumour suppressor genes STK11 and/or KEAP1 can identify patients with advanced non-small-cell lung cancer who are likely to benefit from combinations of PD-(L)1 and CTLA4 immune checkpoint inhibitors added to chemotherapy.

Ferdinandos Skoulidis
Haniel A. Araujo
John V. Heymach
ResearchOpen Access09 Oct 2024
Nature

Volume: 635, P: 462-471
Author Correction: Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression

Rajesha Rupaimoole
Sherry Y. Wu
Anil K. Sood
Amendments and Corrections03 Jun 2020
Nature Communications

Volume: 11, P: 1-2
Author Correction: CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

Ferdinandos Skoulidis
Haniel A. Araujo
John V. Heymach
Amendments and CorrectionsOpen Access27 Feb 2025
Nature

Volume: 639, P: E19
Factor XIIIA—expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking

Lung squamous carcinomas (LUSC) are poorly molecularly characterized, but sub-populations show promising response to immune checkpoint inhibitors. Here, the authors identify a subset of LUSC characterized by infiltration of inflammatory monocytes, where metastasis is linked to Factor XIIIA promoting fibrin cross-linking.

Alessandro Porrello
Patrick L. Leslie
Chad V. Pecot
ResearchOpen Access18 May 2018
Nature Communications

Volume: 9, P: 1-19
Targeting brain lesions of non-small cell lung cancer by enhancing CCL2-mediated CAR-T cell migration

Therapeutic options for non-small cell lung cancer patients with brain metastases are limited. Here the authors design B7-H3 targeting CAR-T cells engineered to express the chemokine receptor CCR2b, and show improved accumulation in the brain and enhanced anti-tumor activity in preclinical models of lung cancer brain metastases.

Hongxia Li
Emily B. Harrison
Hongwei Du
ResearchOpen Access20 Apr 2022
Nature Communications

Volume: 13, P: 1-12
Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER

Reduced expression of DICER—responsible for the processing of microRNA precursors—was previously linked to poor clinical outcomes in cancer patients. Here, the authors uncover an epigenetic mechanism by which hypoxia suppresses DICER expression and deregulates the miR-200-Zeb1 circuit in breast cancer to promote the tumour phenotype.

Twan van den Beucken
Elizabeth Koch
Bradly G. Wouters
Research29 Oct 2014
Nature Communications

Volume: 5, P: 1-13
A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer

The formation of blood vessels in tumours, angiogenesis, is a promising target for therapy. Here, the authors show that microRNA192 has anti-angiogenic functions and negatively regulates EGR1 and HOXB9, and that delivery of this microRNA to tumours in vivocan reduce angiogenesis and tumour growth.

Sherry Y. Wu
Rajesha Rupaimoole
Anil K. Sood
ResearchOpen Access04 Apr 2016
Nature Communications

Volume: 7, P: 1-14
Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression

MicroRNAs play important roles in the maintenance of cellular homeostasis through the post-transcriptional regulation of gene expression. Here, the authors implicate loss of the miRNA biogenesis factor Drosha and altered miRNA maturation in tumour progression under hypoxic conditions.

Rajesha Rupaimoole
Sherry Y. Wu
Anil K. Sood
Research29 Oct 2014
Nature Communications

Volume: 5, P: 1-13
2′-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity

Short interfering siRNAs—siRNAs—have therapeutic potential in the treatment of disease; however, their delivery to target tissues is difficult. Here, Wu et al. chemically modify siRNAs and show that this improves loading into the siRNA silencing machinery and thus efficacy in eliminating cancer cells in mice.

Sherry Y. Wu
Xianbin Yang
Anil K. Sood
Research12 Mar 2014
Nature Communications

Volume: 5, P: 1-12
RNA interference in the clinic: challenges and future directions

Inherent difficulties with blocking many desirable targets using conventional approaches have prompted many to consider using RNA interference (RNAi) as a therapeutic approach. This Review explores current challenges to the development of synthetic RNAi-based therapies and considers new approaches to circumvent biological barriers.

Chad V. Pecot
George A. Calin
Anil K. Sood
Reviews16 Dec 2010
Nature Reviews Cancer

Volume: 11, P: 59-67
Quaking orchestrates a post-transcriptional regulatory network of endothelial cell cycle progression critical to angiogenesis and metastasis

Salma H. Azam
Alessandro Porrello
Chad V. Pecot
Research27 Mar 2019
Oncogene

Volume: 38, P: 5191-5210
Coronin 1C inhibits melanoma metastasis through regulation of MT1-MMP-containing extracellular vesicle secretion

Alicia C. Tagliatela
Stephanie C. Hempstead
James E. Bear
ResearchOpen Access20 Jul 2020
Scientific Reports

Volume: 10, P: 1-16

Search

Tumour angiogenesis regulation by the miR-200 family

Snord67 promotes breast cancer metastasis by guiding U6 modification and modulating the splicing landscape

Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes

CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

Author Correction: Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression

Author Correction: CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

Factor XIIIA—expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking

Targeting brain lesions of non-small cell lung cancer by enhancing CCL2-mediated CAR-T cell migration

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER

A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer

Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression

2′-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity

RNA interference in the clinic: challenges and future directions

Quaking orchestrates a post-transcriptional regulatory network of endothelial cell cycle progression critical to angiogenesis and metastasis

Coronin 1C inhibits melanoma metastasis through regulation of MT1-MMP-containing extracellular vesicle secretion

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