Ambattu et al. report that high frequency acoustic stimulation of mammalian cancer cells promotes exosome generation without affecting cell viability. Acoustic stimulation increases calcium ion influx which triggers an ESCRT pathway related to exosome production. This method may allow for large-scale exosome production with potential clinical applications.
- Lizebona August Ambattu
- Shwathy Ramesan
- Leslie Y. Yeo
