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Showing 1–6 of 6 results
Advanced filters: Author: Chak Shun Yu Clear advanced filters

  • Giles et al. developed a method for noninvasive absorbance measurement of mitochondrial hemes to monitor the mitochondrial membrane potential in the perfused heart. They then applied this approach to show how the mitochondrial membrane potential changed during cardiac ischemia.

    • Abigail V. Giles
    • Raul Covian
    • Robert S. Balaban
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 4, P: 1627-1641

  • Hydrogen sulfide (H2S) reversibly modifies low molecular weight and protein thiols to form persulfides (RSS−) and polysulfides (RS(S)nS−) for antioxidant defence and regulation of activity. Here, the authors report a sensitive LC-MS/MS procedure that separately traps and quantifies the sulfur atom of H2S, the terminal sulfur atom of RSS and RS(S)nS-, and the internal sulfur atoms of RS(S)nS − as diagnostic products in biological samples.

    • Jan Lj. Miljkovic
    • Nils Burger
    • Michael P. Murphy
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-19

  • Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages carrying this mutation display altered function and metabolism in vitro, along with increased type I IFN release following LPS challenge in vivo.

    • Eloïse Marques
    • Stephen P. Burr
    • Dylan G. Ryan
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-24

  • Epstein–Barr virus - host chromatin interactions in nasopharyngeal carcinoma remain poorly understood. Here, the authors characterise the virus‒host chromatin interactions leading to genome reorganisation and identify a KDM5B-relevant signature associated with distant metastasis.

    • Dittman Lai-Shun Chung
    • Zhaozheng Hou
    • Wei Dai
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21

  • Heart failure is characterised by a detrimental rise in the intracellular sodium concentration. Here the authors show that this reversibly reprogrammes energy metabolism in the heart making this a possible therapeutic target for the development of new drugs.

    • Yu Jin Chung
    • Zoe Hoare
    • Michael J. Shattock
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • The transition of HIV and AIDS from a death sentence to a chronic disease has not come without problems. Rheumatologists need to be aware of the full spectrum of rheumatic diseases seen in patients with HIV and AIDS, and know the best strategies for disease management.

    • Chak-Sing Lau
    • Philip Li
    News & Views
    Nature Reviews Rheumatology
    Volume: 13, P: 8-10