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Showing 1–11 of 11 results
Advanced filters: Author: Chan-Wang J. Lio Clear advanced filters

  • Huang and colleagues report that TIM4–AMPK signaling induces downregulation of the mitochondrial HSP90 chaperone TRAP1 in tumor-associated macrophages, thereby enhancing their immunoinhibitory function and promoting immune evasion and tumorigenesis.

    • Haoxin Zhao
    • Jaeoh Park
    • Stanley Ching-Cheng Huang
    Research
    Nature Immunology
    Volume: 26, P: 2185-2200

  • Transfer of NR4A-deficient T cells expressing chimeric antigen receptors is shown to reduce tumour burden and increase survival by shifting T cell transcriptional programs away from exhaustion and towards increased effector function.

    • Joyce Chen
    • Isaac F. López-Moyado
    • Anjana Rao
    Research
    Nature
    Volume: 567, P: 530-534

  • Loss of TET proteins in immune cell populations is known to result in immunopathology. Here the authors show that deficiency of Tet2 and Tet3 proteins, specifically in the CD4+ FoxP3+ Treg lineage, results in a dominant pathology in which ex-Treg cells and bystander T cells gain aberrant effector function.

    • Xiaojing Yue
    • Chan-Wang J. Lio
    • Anjana Rao
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Chronic antigen stimulation leads to CD8+ T cell exhaustion, which is mediated by persistent activation of the transcription factor NFAT in the absence of AP-1. Seo, González-Avalos and colleagues show that overexpressed BATF cooperates with IRF4 to counteract NFAT-induced exhaustion and promote better tumor control by CAR T cells in mouse models.

    • Hyungseok Seo
    • Edahí González-Avalos
    • Patrick G. Hogan
    Research
    Nature Immunology
    Volume: 22, P: 983-995

  • The transcriptional regulator PLZF controls many of the key effector functions of invariant natural killer T (iNKT) cells but it is not clear how PLZF itself is regulated. Here, Pereira et al. demonstrate that a methlytransferase Jarid2 regulates PLZF expression and thus controls iNKT cell maturation.

    • Renata M. Pereira
    • Gustavo J. Martinez
    • Anjana Rao
    Research
    Nature Communications
    Volume: 5, P: 1-14

  • How are regulatory T (TReg) cells selected in the thymus? What is the role of T cell receptor specificity in the generation of self antigen-specific TReg cells? What is the involvement of thymic antigen-presenting cells in TReg cell differentiation and how is FOXP3 expression induced in developing thymocytes? Here, the authors summarize the latest findings in the field of TRegcells to provide answers to these long-standing questions.

    • Chyi-Song Hsieh
    • Hyang-Mi Lee
    • Chan-Wang J. Lio
    Reviews
    Nature Reviews Immunology
    Volume: 12, P: 157-167