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Showing 1–3 of 3 results
Advanced filters: Author: Chan-Wang Jerry Lio Clear advanced filters

  • Huang and colleagues report that TIM4–AMPK signaling induces downregulation of the mitochondrial HSP90 chaperone TRAP1 in tumor-associated macrophages, thereby enhancing their immunoinhibitory function and promoting immune evasion and tumorigenesis.

    • Haoxin Zhao
    • Jaeoh Park
    • Stanley Ching-Cheng Huang
    Research
    Nature Immunology
    Volume: 26, P: 2185-2200

  • How are regulatory T (TReg) cells selected in the thymus? What is the role of T cell receptor specificity in the generation of self antigen-specific TReg cells? What is the involvement of thymic antigen-presenting cells in TReg cell differentiation and how is FOXP3 expression induced in developing thymocytes? Here, the authors summarize the latest findings in the field of TRegcells to provide answers to these long-standing questions.

    • Chyi-Song Hsieh
    • Hyang-Mi Lee
    • Chan-Wang J. Lio
    Reviews
    Nature Reviews Immunology
    Volume: 12, P: 157-167