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Showing 1–8 of 8 results
Advanced filters: Author: Chandler Gatenbee Clear advanced filters

  • Integration of mathematical modeling, ecological analyses of patient biopsies, and neoantigen heterogeneity suggests recruitment of immunosuppressive cells is key to initializing transformation from adenoma to carcinoma in human colorectal cancer.

    • Chandler D. Gatenbee
    • Ann-Marie Baker
    • Alexander R. A. Anderson
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • The spatial organization of a tumor affects how it grows and responds to treatment. Here, the authors present VALIS, a software to align sets of whole slide images (WSI) with state-of-the-art accuracy, enabling spatial studies of the tumor ecology.

    • Chandler D. Gatenbee
    • Ann-Marie Baker
    • Alexander R. A. Anderson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Some cancers occur in spatially constrained tissues such as the mammary gland, and how the morphological features influence the evolution of the cancer is unclear. Here, the authors use mathematical modeling to study the question of competition for space and provide inferences on the mode of evolution of cancers in such tissues.

    • Jeffrey West
    • Ryan O. Schenck
    • Alexander R. A. Anderson
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • In patients with high-grade serous ovarian cancer, robust and protective humoral responses are dominated by B-cell-derived polyclonal IgA that binds to polymeric IgA receptors that are universally expressed on ovarian cancer cells.

    • Subir Biswas
    • Gunjan Mandal
    • Jose R. Conejo-Garcia
    ResearchOpen Access
    Nature
    Volume: 591, P: 464-470

  • Genome sequence data from colorectal tumours show how adenomas progress to carcinomas on the fitness landscape.

    • William Cross
    • Michal Kovac
    • Ian P. M. Tomlinson
    Research
    Nature Ecology & Evolution
    Volume: 2, P: 1661-1672

  • Mathematical modeling of evolutionary dynamics of neoantigens and immune escape in growing tumors shows that strong negative selection for neoantigens inhibits tumor growth but also provides a strong selective pressure for the evolution of immune escape.

    • Eszter Lakatos
    • Marc J. Williams
    • Trevor A. Graham
    Research
    Nature Genetics
    Volume: 52, P: 1057-1066