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Showing 1–8 of 8 results
Advanced filters: Author: Changbong Hyeon Clear advanced filters

  • Interactions between (SNARE) proteins on vesicle and target membranes provide the force necessary to drive membrane fusion. By applying piconewton forces to single SNARE complexes, the authors identify a partially assembled intermediate state that reveals how force is generated in a consistent direction.

    • Duyoung Min
    • Kipom Kim
    • Tae-Young Yoon
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-10

  • The typical method for DNA origami fabrication uses thermal annealing of staples to a longer DNA scaffold. Here, the authors present a mechanical method to control the folding pathway, which instead relies on stretching the DNA scaffold in magnetic tweezers, prior to staple incorporation.

    • Wooli Bae
    • Kipom Kim
    • Tae-Young Yoon
    Research
    Nature Communications
    Volume: 5, P: 1-8

  • Co-immunoprecipitation provides static and qualitative information about protein–protein interactions. Lee et al.create real-time movies of single protein–protein interactions during co-immunoprecipitation, and use them to assess the dynamics of mutant Ras proteins derived from tumours.

    • Hong-Won Lee
    • Taeyoon Kyung
    • Tae-Young Yoon
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-9

  • Fueled by ATP hydrolysis in N-ethylmaleimide sensitive factor (NSF), the 20S complex disassembles SNARE complexes in a single unravelling step. Here authors use single-molecule methods to show cooperativity between the NSF and SNARE complex, which prevents ATP consumption without productive disassembly.

    • Changwon Kim
    • Min Ju Shon
    • Tae-Young Yoon
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Single-molecule experiments reveal substantial molecule-to-molecule variation in the Mg2+-induced isomerization dynamics of Holliday junctions (HJs). Effective ergodicity breaking of time trajectories results in the partitioning of HJ dynamics into multiple clusters. The observed dynamical heterogeneity is a consequence of various internal multiloop conformations that are frozen by Mg2+ ions.

    • Changbong Hyeon
    • Jinwoo Lee
    • D. Thirumalai
    Research
    Nature Chemistry
    Volume: 4, P: 907-914

  • Metal ions at the active site of an enzyme act as cofactors and their dynamic fluctuations might influence enzyme activity. Here authors use single-molecule FRET to study λ-exonuclease and find that metal-ion-coordination is correlated with enzymatic reaction-steps.

    • Wonseok Hwang
    • Jungmin Yoo
    • Gwangrog Lee
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • The 3D organization of chromosomes within the nuclear space is important for biological functions. Here the authors model chromosomes as self-avoiding copolymers with distinct epigenetic states, and show that the features of experimentally generated contact maps can be reproduced and their dynamics predicted.

    • Guang Shi
    • Lei Liu
    • D. Thirumalai
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13