Nature Search

The UFL1-AKT positive feedback loop promotes breast cancer progression by enhancing lipid synthesis

The role of protein UFMylation in cancer remains to be understood. Here, the authors show that UFM1-specific ligase 1 and AKT positively regulate each other through UFMylation and phosphorylation, facilitating lipid synthesis and breast tumor growth.

Fei Meng
Yating Du
Yan Chen
ResearchOpen Access20 Jan 2026
Nature Communications

Volume: 17, P: 1-18
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling

Chen and colleagues report that the third enzyme in the oxidative pentose phosphate pathway (PPP), 6PGD, controls cancer cell proliferation by regulating LKB1–AMPK signalling. Inhibitors of 6PGD decrease tumorigenesis in mouse xenografts.

Ruiting Lin
Shannon Elf
Jing Chen
Research19 Oct 2015
Nature Cell Biology

Volume: 17, P: 1484-1496
Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation

Copper is a transition metal ion essential for the regulation of cellular oxidative stress and ATP production. Now, the inhibition of copper-trafficking proteins by a small molecule has been shown to significantly reduce proliferation of cancer cells. The results indicate that copper-trafficking proteins could represent new anti-tumour therapeutic targets.

Jing Wang
Cheng Luo
Chuan He
Research09 Nov 2015
Nature Chemistry

Volume: 7, P: 968-979
Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation

Tumour cells may undergo a dramatic metabolic shift in which glycolysis is favoured despite the presence of oxygen. By solving its crystal structure, Hitosugi et al. reveal how phosphorylation of the enzyme phosphoglycerate mutase 1 regulates glycolytic flux in cancer cells.

Taro Hitosugi
Lu Zhou
Jing Chen
Research30 Apr 2013
Nature Communications

Volume: 4, P: 1-10
4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis

Changliang Shan
Zhaoliang Lu
Shuai Zhang
ResearchOpen Access08 Jul 2019
Cell Death & Disease

Volume: 10, P: 1-13
Correction to: Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation

Shuai Zhang
Hao Sheng
Keqiang Ye
Amendments and CorrectionsOpen Access12 Jun 2025
Cell Death & Disease

Volume: 16, P: 1
Correction: 4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis

Changliang Shan
Zhaoliang Lu
Shuai Zhang
Amendments and CorrectionsOpen Access26 Feb 2025
Cell Death & Disease

Volume: 16, P: 1-4
Correction: Ciclopirox activates PERK-dependent endoplasmic reticulum stress to drive cell death in colorectal cancer

Jianjun Qi
Ningning Zhou
Bin Lu
Amendments and CorrectionsOpen Access03 Sept 2020
Cell Death & Disease

Volume: 11, P: 1
Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation

Shuai Zhang
Hao Sheng
Keqiang Ye
ResearchOpen Access04 Mar 2019
Cell Death & Disease

Volume: 10, P: 1-13
Ciclopirox activates PERK-dependent endoplasmic reticulum stress to drive cell death in colorectal cancer

Jianjun Qi
Ningning Zhou
Bin Lu
ResearchOpen Access27 Jul 2020
Cell Death & Disease

Volume: 11, P: 1-16
Cell-cycle-dependent phosphorylation of RRM1 ensures efficient DNA replication and regulates cancer vulnerability to ATR inhibition

Zhen Shu
Zhen Li
Guo Chen
Research25 Jul 2020
Oncogene

Volume: 39, P: 5721-5733
Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2

Changliang Shan
Fuqing Xu
Xiaodong Zhang
Research13 Apr 2010
Cell Research

Volume: 20, P: 563-575

Search

Filter By:

Search

Quick links