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Experimental & Molecular Medicine (7)
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Showing 1–14 of 14 results

Advanced filters: Author: Changyoun Kim Clear advanced filters

Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells

Changyoun Kim
Somin Kwon
Eliezer Masliah
ResearchOpen Access16 Feb 2021
Experimental & Molecular Medicine

Volume: 53, P: 281-290
Retraction Note: Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies

Changyoun Kim
Armine Hovakimyan
Michael G. Agadjanyan
Amendments and CorrectionsOpen Access12 Mar 2025
npj Vaccines

Volume: 10, P: 1
Redirecting microglia phenotype via inhibition of NFAT1 ameliorates deficits in mouse model of synucleinopathies

Michiyo Iba
Yeon-Joo Lee
Changyoun Kim
ResearchOpen Access17 Nov 2025
Experimental & Molecular Medicine

Volume: 57, P: 2588-2607
Does SARS-CoV-2 affect neurodegenerative disorders? TLR2, a potential receptor for SARS-CoV-2 in the CNS

Marcell P. Szabo
Michiyo Iba
Changyoun Kim
ReviewsOpen Access08 Apr 2022
Experimental & Molecular Medicine

Volume: 54, P: 447-454
Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

Parkinson’s disease is associated with the accumulation of abnormal aggregates of α-synuclein and microglial neuroinflammation. Kim et al. show that α-synuclein oliogomers released by neurons activate microglia by stimulating Toll-like receptor 2 signalling in these cells.

Changyoun Kim
Dong-Hwan Ho
Seung-Jae Lee
Research05 Mar 2013
Nature Communications

Volume: 4, P: 1-12
A new synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), suppresses the Toll-like receptor 4-mediated inflammatory response through inhibition of the Akt/NF-κB pathway in BV2 microglial cells

Young Han Lee
Seung-Hyun Jeon
Soon Young Shin
ResearchOpen Access29 Feb 2012
Experimental & Molecular Medicine

Volume: 44, P: 369-377
Author Correction: Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies

Changyoun Kim
Armine Hovakimyan
Michael G. Agadjanyan
Amendments and CorrectionsOpen Access17 Jul 2023
npj Vaccines

Volume: 8, P: 1-2
LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation

Mutations in LRRK2 kinase are associated with Parkinson’s disease. Here the authors show that LRRK2 modulates propagation of α-synuclein, using rodent and C. elegans models, and show that this is dependent on phosphorylation of one of its substrates, RAB35.

Eun-Jin Bae
Dong-Kyu Kim
Seung-Jae Lee
ResearchOpen Access27 Aug 2018
Nature Communications

Volume: 9, P: 1-16
Correction: TNF-α promotes α-synuclein propagation through stimulation of senescence-associated lysosomal exocytosis

Eun-Jin Bae
Minsun Choi
Seung-Jae Lee
Amendments and CorrectionsOpen Access01 Apr 2024
Experimental & Molecular Medicine

Volume: 56, P: 1027-1028
A compendium of promoter-centered long-range chromatin interactions in the human genome

Mapping long-range chromatin interactions in 27 human cell/tissue types identifies candidate target genes of 70,329 putative regulatory elements. Further analysis suggests potential regulatory function for 27,325 noncoding variants associated with 2,117 traits and diseases.

Inkyung Jung
Anthony Schmitt
Bing Ren
Research09 Sept 2019
Nature Genetics

Volume: 51, P: 1442-1449
RETRACTED ARTICLE: Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies

Changyoun Kim
Armine Hovakimyan
Michael G. Agadjanyan
ResearchOpen Access10 Jan 2022
npj Vaccines

Volume: 7, P: 1-16
TNF-α promotes α-synuclein propagation through stimulation of senescence-associated lysosomal exocytosis

Eun-Jin Bae
Minsun Choi
Seung-Jae Lee
ResearchOpen Access05 Jul 2022
Experimental & Molecular Medicine

Volume: 54, P: 788-800
Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril

Changyoun Kim
Guohua Lv
Seung-Jae Lee
ResearchOpen Access04 Aug 2016
Scientific Reports

Volume: 6, P: 1-12
β1-integrin-dependent migration of microglia in response to neuron-released α-synuclein

Changyoun Kim
Eun-Deok Cho
Seung-Jae Lee
ResearchOpen Access18 Apr 2014
Experimental & Molecular Medicine

Volume: 46, P: e91