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Showing 1–3 of 3 results
Advanced filters: Author: Chani Park Clear advanced filters

  • Synthetic lethality (SL) offers a new precision oncology approach, which is based on targeting cancer-specific vulnerabilities across the whole genome, going beyond cancer drivers. The authors develop an approach termed ISLE to identify clinically relevant SL interactions and use them for patient stratification and novel target identification.

    • Joo Sang Lee
    • Avinash Das
    • Eytan Ruppin
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Genetic analyses of ancestrally diverse populations show evidence of heterogeneity across ancestries and provide insights into clinical implications, highlighting the importance of including ancestrally diverse populations to maximize genetic discovery and reduce health disparities.

    • Genevieve L. Wojcik
    • Mariaelisa Graff
    • Christopher S. Carlson
    Research
    Nature
    Volume: 570, P: 514-518