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Showing 1–6 of 6 results
Advanced filters: Author: Chani Stossel Clear advanced filters

  • Despite being a hallmark of cancer, the identification of targetable vulnerabilities of aneuploid cancer cells remains limited. Here, the authors develop RPE1-hTERT cell lines with varying degrees of aneuploidy to investigate the consequences of chromosomal imbalance, identifying CRAF as an aneuploid-selective therapeutically targetable vulnerability.

    • Johanna Zerbib
    • Marica Rosaria Ippolito
    • Stefano Santaguida
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • Deep phenotyping of an ancestrally diverse group of 13,000 individuals in the Human Phenotype Project highlights diversity and variations in lifestyle factors, clinical features and molecular signatures of health and disease.

    • Lee Reicher
    • Smadar Shilo
    • Eran Segal
    Research
    Nature Medicine
    Volume: 31, P: 3191-3203

  • A study identifies 41 consensus gene expression meta-programs that are coordinately upregulated in subpopulations of malignant cells across tumour types, providing a comprehensive picture of hallmarks of intratumour heterogeneity.

    • Avishai Gavish
    • Michael Tyler
    • Itay Tirosh
    Research
    Nature
    Volume: 618, P: 598-606

  • Synthetic lethality (SL) offers a new precision oncology approach, which is based on targeting cancer-specific vulnerabilities across the whole genome, going beyond cancer drivers. The authors develop an approach termed ISLE to identify clinically relevant SL interactions and use them for patient stratification and novel target identification.

    • Joo Sang Lee
    • Avinash Das
    • Eytan Ruppin
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12