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Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

Alexis M. Kalergis
Nicole Boucheron
Stanley G. Nathenson
Research01 Mar 2001
Nature Immunology

Volume: 2, P: 229-234
Intragenic DNA inversions expand bacterial coding capacity

Reversible DNA inversions found entirely within genes enable increased coding capacity by encoding multiple versions of a protein in bacteria and archaea.

Rachael B. Chanin
Patrick T. West
Ami S. Bhatt
Research25 Sept 2024
Nature

Volume: 634, P: 234-242
REDD1 promotes obesity-induced metabolic dysfunction via atypical NF-κB activation

The stress response protein REDD1 is regulates inflammation and energy metabolism. Here the authors report that global or adipocyte-specific deletion of REDD1 inhibits diet induced obesity, insulin resistance, liver steatosis and inflammation in mice, at least in part via reduced atypical NF-κB activation.

Dong-Keon Lee
Taesam Kim
Young-Myeong Kim
ResearchOpen Access22 Oct 2022
Nature Communications

Volume: 13, P: 1-16
Novel chemical scaffolds of the tumor marker AKR1B10 inhibitors discovered by 3D QSAR pharmacophore modeling

Raj Kumar
Minky Son
Keun Woo Lee
Research08 Jun 2015
Acta Pharmacologica Sinica

Volume: 36, P: 998-1012
Activated TCRs remain marked for internalization after dissociation from pMHC

Daniel Coombs
Alexis M. Kalergis
Byron Goldstein
Research09 Sept 2002
Nature Immunology

Volume: 3, P: 926-931
Molecular determinants of selective clearance of protein inclusions by autophagy

Dysfunctional or aggregated proteins in cells are degraded by autophagy. Wong et al.study aggregates of the protein synphilin-1 and show that ubiquitination alters their dynamic properties, which determines whether the aggregates are degraded via basal or inducible forms of autophagy.

Esther Wong
Eloy Bejarano
Ana Maria Cuervo
Research04 Dec 2012
Nature Communications

Volume: 3, P: 1-13
MafB deficiency causes defective respiratory rhythmogenesis and fatal central apnea at birth

Bruno Blanchi
Louise M Kelly
Michael H Sieweke
Research25 Sept 2003
Nature Neuroscience

Volume: 6, P: 1091-1100
M1 macrophages polarized by crude polysaccharides isolated from Auricularia polytricha exhibit anti-tumor effect on human breast cancer cells

Sunita Nilkhet
Kuljira Mongkolpobsin
Siriporn Chuchawankul
ResearchOpen Access08 Apr 2024
Scientific Reports

Volume: 14, P: 1-13
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

Alberto Martin
Philip D. Bardwell
Matthew D. Scharff
Research30 Jan 2002
Nature

Volume: 415, P: 802-806
Next-generation sequencing for pediatric-onset neuromuscular disorders unresolved by conventional diagnostic methods

Pimchanok Kulsirichawaroj
Mongkol Chanvanichtrakool
Stephan Zuchner
ResearchOpen Access10 Jun 2025
Pediatric Research

Volume: 98, P: 2195-2202
Chaperone-mediated autophagy: Dice's 'wild' idea about lysosomal selectivity

This timeline article pays tribute to the late James Fred 'Paulo' Dice, whose vision of selective protein degradation in lysosomes led to the discovery of chaperone-mediated autophagy.

Ana Maria Cuervo
Reviews13 Jul 2011
Nature Reviews Molecular Cell Biology

Volume: 12, P: 535-541
AID and mismatch repair in antibody diversification

Alberto Martin
Matthew D. Scharff
Reviews01 Aug 2002
Nature Reviews Immunology

Volume: 2, P: 605-614
Trophic macrophages in development and disease

The homeostatic roles of macrophages in tissue development and maintenance are discussed, and insights are provided into how dysregulation of these primitive functions can be subverted in chronic diseases such as cancer and obesity to contribute to pathology.

Jeffrey W. Pollard
Reviews01 Apr 2009
Nature Reviews Immunology

Volume: 9, P: 259-270
Chaperone-mediated autophagy: roles in disease and aging

Ana Maria Cuervo
Esther Wong
Reviews26 Nov 2013
Cell Research

Volume: 24, P: 92-104

Search

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

Intragenic DNA inversions expand bacterial coding capacity

REDD1 promotes obesity-induced metabolic dysfunction via atypical NF-κB activation

Novel chemical scaffolds of the tumor marker AKR1B10 inhibitors discovered by 3D QSAR pharmacophore modeling

Activated TCRs remain marked for internalization after dissociation from pMHC

Molecular determinants of selective clearance of protein inclusions by autophagy

MafB deficiency causes defective respiratory rhythmogenesis and fatal central apnea at birth

M1 macrophages polarized by crude polysaccharides isolated from Auricularia polytricha exhibit anti-tumor effect on human breast cancer cells

Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

Next-generation sequencing for pediatric-onset neuromuscular disorders unresolved by conventional diagnostic methods

Chaperone-mediated autophagy: Dice's 'wild' idea about lysosomal selectivity

AID and mismatch repair in antibody diversification

Trophic macrophages in development and disease

Chaperone-mediated autophagy: roles in disease and aging

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