Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–14 of 14 results
Advanced filters: Author: Chantal LeBlanc Clear advanced filters
  • In both focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN), kidney injury is characterised by the invasion of glomerular tufts by parietal epithelial cells (PECs). Here Lazareth et al. identify the tetraspanin CD9 as a key regulator of PEC migration, and find its upregulation in FSGS and CGN contributes to kidney injury in both diseases.

    • Hélène Lazareth
    • Carole Henique
    • Pierre-Louis Tharaux
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17
  • Active DNA demethylation is required for sexual reproduction in plants, but the underlying mechanisms are unknown. Here, the authors show that the DNA glycosylases DEMETER and REPRESSOR OF SILENCING 1 enable the DNA demethylation-dependent activation of genes involved in pollen tube progression.

    • Souraya Khouider
    • Filipe Borges
    • Daniel Bouyer
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10
  • Covalent histone modifications can affect the structure of chromatin. Expression of underlying monomethylated histone H3K27 is associated with chromocenters in Arabidopsis, but its presence is unaffected by mutations in the expected methyltransferases. Data now indicate that this modification is catalyzed by Arabidopsis ATRX5 and ATXR6 and is required for silencing, but in a pathway independent of that involving DNA methyltransferases.

    • Yannick Jacob
    • Suhua Feng
    • Scott D Michaels
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 763-768
  • A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

    • Philippe Bégin
    • Jeannie Callum
    • Donald M. Arnold
    ResearchOpen Access
    Nature Medicine
    Volume: 27, P: 2012-2024
  • Microvesicles—extracellular vesicles released by virtually all cells—are now implicated in key processes of liver diseases including fibrosis and complications of cirrhosis and hepatocellular carcinoma. This Review describes studies assessing circulating microvesicle levels in patients with liver diseases, together with an insight into the mechanisms that could account for these changes. The potential of microvesicles as biomarkers in liver diseases is also discussed.

    • Sara Lemoinne
    • Dominique Thabut
    • Pierre-Emmanuel Rautou
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 11, P: 350-361
  • During transformation via Agrobacterium tumefaciens, sequence composition of T-DNA (that is, DNA repeats) affects T-DNA concatenation in Arabidopsis. In addition, loss of specific DNA repair proteins dramatically decreases T-DNA concatenation levels. This study showcases the potential of T-DNA concatenation as a tool to enhance gene editing.

    • Lauren Dickinson
    • Wenxin Yuan
    • Yannick Jacob
    Research
    Nature Plants
    Volume: 9, P: 1398-1408
  • Extracellular vesicles regulate the transfer of biological information, acting locally and remotely. Interest in extracellular vesicles, in particular exosomes, in the cardiovascular field emerged a decade ago, opening new research and therapeutic avenues. This Review summarizes current knowledge on the role of extracellular vesicles in coronary artery disease, and their emerging potential as biomarkers and therapeutic agents.

    • Chantal M. Boulanger
    • Xavier Loyer
    • Nicolas Amabile
    Reviews
    Nature Reviews Cardiology
    Volume: 14, P: 259-272
  • DNA replication occurs only once per cell cycle, and numerous pathways prevent re-replication. Here it is shown that mutations in ARABIDOPSIS TRITHORAX-RELATED PROTEIN5 (ATXR5) and ATXR6 — which encode histone methyltransferases — lead to re-replication of specific genomic locations, notably those corresponding to transposons and other repetitive and silenced elements. ATXR5 and ATXR6 are proposed to be components of a pathway that prevents over-replication of heterochromatin in Arabidopsis.

    • Yannick Jacob
    • Hume Stroud
    • Steven E. Jacobsen
    Research
    Nature
    Volume: 466, P: 987-991
  • Here, Zuber et al., on behalf of the French Study Group for aHUS/C3G, discuss the role of eculizumab in the treatment of atypical haemolytic uraemic syndrome (aHUS). They review data from case reports and preliminary data from prospective trials, present their opinions, and describe issues that require further study. In addition, they discuss the potential use of eculizumab in C3 glomerulopathies.

    • Julien Zuber
    • Fadi Fakhouri
    • Véronique Frémeaux-Bacchi
    Reviews
    Nature Reviews Nephrology
    Volume: 8, P: 643-657
  • Postrenal transplant hemolytic uremic syndrome (HUS) can occur as a recurrent orde novodisease. Improved understanding of the mechanisms by which atypical HUS occurs after transplantation should result in the improved management of affected patients. In this Review, Zuber and colleagues discuss recent advances in our understanding of the pathogenesis of atypical HUS and describe diagnostic and therapeutic considerations with regard to renal transplantation in these patients.

    • Julien Zuber
    • Moglie Le Quintrec
    • Christophe Legendre
    Reviews
    Nature Reviews Nephrology
    Volume: 7, P: 23-35