Zhao et al. uncouple the effects of body temperature and metabolic rate on lifespan in two rodent models, showing that in warm conditions, where body temperature is elevated and metabolic rate reduced, lifespan is reduced. Reversal of increased body temperature reverses the negative impact of high ambient temperatures on lifespan despite lowered metabolic rate.
- Zhijun Zhao
- Jing Cao
- John R. Speakman
