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Showing 1–5 of 5 results
Advanced filters: Author: Chari M. Noddings Clear advanced filters

  • Algae hold great promise for biofuel and chemical production but their use as model systems is hampered by the absence of suitable genetic tools. Here Karas et al. present a nuclear episomal vector for diatoms that is maintained in the absence of antibiotics, and a plasmid delivery method via conjugation with E. coli.

    • Bogumil J. Karas
    • Rachel E. Diner
    • Philip D. Weyman
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • Cryogenic electron microscopy structures reveal how the immunophilin co-chaperones, FKBP51 and FKBP52, each engage Hsp90–client complexes to directly stabilize a folded, ligand-bound client, the glucocorticoid receptor, and promote the next stage of client maturation.

    • Chari M. Noddings
    • Jill L. Johnson
    • David A. Agard
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 1867-1877

  • The cryo-electron microscopy structure of the glucocorticoid receptor (GR)-loading complex—a complex in which Hsp70 loads GR onto Hsp90 and Hop—is described, providing insights into how the chaperones Hsp90 and Hsp70 coordinate to facilitate GR remodelling for activation.

    • Ray Yu-Ruei Wang
    • Chari M. Noddings
    • David A. Agard
    Research
    Nature
    Volume: 601, P: 460-464