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Showing 1–6 of 6 results
Advanced filters: Author: Charles Bou-Nader Clear advanced filters

  • The J2 antibody is widely used for detecting double-stranded RNAs. Here, Bou-Nader et al. define its nucleic acid specificity and recognition mechanism by solving its co-crystal structure bound to dsRNA, establishing a framework for its reliable use in RNA detection.

    • Charles Bou-Nader
    • Kevin M. Juma
    • Jinwei Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-16

  • The S9.6 monoclonal antibody is widely used to map R-loops genome wide. Here, Bou-Nader et al., define the nucleic acid-binding specificity of S9.6 and report its crystal structures free and bound to a hybrid, which reveal the asymmetric recognition of the RNA and DNA strands and its A-form conformation.

    • Charles Bou-Nader
    • Ankur Bothra
    • Jinwei Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • The bacterial thymidylate synthase ThyX catalyzes the reductive methylation of deoxyuridylate (dUMP) into deoxythymidylate (dTMP) and requires both folate and flavin for activity. Here, the authors combine biochemical experiments, spectroscopic measurements and flavin synthesis chemistry to show that formaldehyde (CH2O) can replace the natural methylene donor of ThyX in a CH2O-shunt reaction, yielding a carbinolamine intermediate with the reduced flavin coenzyme, and they present the crystal structure of this intermediate.

    • Charles Bou-Nader
    • Frederick W. Stull
    • Djemel Hamdane
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-8

  • The authors uncover a Père David’s deer-like design for long noncoding RNAs such as metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), which partially mimics the transfer RNA (tRNA) structure to recruit select tRNA processing enzymes for maturation and to create novel regulatory RNAs such as the MALAT1-associated small cytoplasmic RNA.

    • Ilias Skeparnias
    • Charles Bou-Nader
    • Jinwei Zhang
    Research
    Nature Structural & Molecular Biology
    Volume: 31, P: 1655-1668

  • Adenovirus Virus-Associated (VA) noncoding RNAs interfere with the host system by mimicking double stranded RNAs. Here, the authors report a 2.7 Å crystal structure of VA-I RNA providing an understanding of its function.

    • Iris V. Hood
    • Jackson M. Gordon
    • Jinwei Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12