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Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts

Regeneration of the heart muscle after myocardial infarction with cardiomyocytes derived from human embryonic stem cells is demonstrated in non-human primates, with the grafts showing evidence of electromechanical coupling, although they were also associated with non-fatal arrhythmias.

James J. H. Chong
Xiulan Yang
Charles E. Murry
Research30 Apr 2014
Nature

Volume: 510, P: 273-277
Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias

Selvakumar, Clayton et al. use a porcine model of myocardial infarction and PSC-CM transplantation and identify atrial and pacemaker-like cardiomyocytes as the cause of engraftment arrhythmias and surface marker signatures to distinguish between arrhythmogenic and non-arrhythmogenic cardiomyocytes.

Dinesh Selvakumar
Zoe E. Clayton
James J. H. Chong
ResearchOpen Access06 Feb 2024
Nature Cardiovascular Research

Volume: 3, P: 145-165
Human embryonic stem cell–derived cardiomyocytes restore function in infarcted hearts of non-human primates

Cardiomyocyte transplantation after heart attack improves contractile function in monkeys.

Yen-Wen Liu
Billy Chen
Charles E Murry
Research02 Jul 2018
Nature Biotechnology

Volume: 36, P: 597-605
Epicardial cells derived from human embryonic stem cells augment cardiomyocyte-driven heart regeneration

Cell therapy in a rat model of heart attack is enhanced by stem-cell-derived epicardium.

Johannes Bargehr
Lay Ping Ong
Sanjay Sinha
Research02 Aug 2019
Nature Biotechnology

Volume: 37, P: 895-906
Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory

The spatial organization of the genome plays an important but unclearly defined role in gene regulation. Here, the authors integrate Hi-C, RNA-seq and ATAC-seq data to map cardiogenesis from pluripotent stem cells and describe an RBM20-dependent splicing factory assembling the TTN locus with other RBM20 targets.

Alessandro Bertero
Paul A. Fields
Charles E. Murry
ResearchOpen Access04 Apr 2019
Nature Communications

Volume: 10, P: 1-19
Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine

In this Review, Murry and colleagues describe the hallmarks of cardiomyocyte maturation and the current approaches to mature stem cell-derived cardiomyocytes, highlighting challenges and future directions to generate cardiomyocytes with an optimal maturation state for use in research and regenerative medicine.

Elaheh Karbassi
Aidan Fenix
Charles E. Murry
Reviews03 Feb 2020
Nature Reviews Cardiology

Volume: 17, P: 341-359
Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies

Mutations in the splicing factor RBM20 cause aggressive Dilated Cardiomyopathy. Here the authors generated RBM20 R636S mutants and knockout in human iPSC-derived cardiomyocytes. Mutant RBM20 showed different target RNA binding, altered splicing and localization to cytoplasmic processing bodies.

Aidan M. Fenix
Yuichiro Miyaoka
Nathan Salomonis
ResearchOpen Access03 Nov 2021
Nature Communications

Volume: 12, P: 1-14
Erratum: Human embryonic stem cell–derived cardiomyocytes restore function in infarcted hearts of non-human primates

Yen-Wen Liu
Billy Chen
Charles E Murry
Amendments and Corrections02 Jul 2018
Nature Biotechnology

Volume: 36, P: 899
Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts

Charles E. Murry
Mark H. Soonpaa
Loren J. Field
Research21 Mar 2004
Nature

Volume: 428, P: 664-668
The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy

Mutation of LMNA, encoding Lamin A/C nuclear proteins, cause dilated cardiomyopathy and conduction disorders. Here, the authors show that patient-specific iPSC-derived CMs carrying the K219T LMNA mutation have downregulated Na_v1.5 channels due to dynamic cooperation of Lamin A/C and Polycomb repressor complex 2 at the SCN5A promoter.

Nicolò Salvarani
Silvia Crasto
Elisa Di Pasquale
ResearchOpen Access22 May 2019
Nature Communications

Volume: 10, P: 1-16
Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts

Michael A Laflamme
Kent Y Chen
Charles E Murry
Research26 Aug 2007
Nature Biotechnology

Volume: 25, P: 1015-1024
Reprogramming the injured heart

When the heart is injured, the muscle does not regenerate and scars are produced. This process can be attenuated in the hearts of live mice by forcing scar-forming cells to become muscle cells. See Articles p.593 & p.599

Nathan J. Palpant
Charles E. Murry
News & Views31 May 2012
Nature

Volume: 485, P: 585-586
Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts

Heart grafts need good vascularization to survive. Here, the authors engineer perfusable constructs of human embryonic stem cell-derived endothelial cells seeded in collagen matrix in patterned microchannels that form anastomosed vessels in vitro and have increased coronary vascular perfusion on transplantation in rats.

Meredith A. Redd
Nicole Zeinstra
Ying Zheng
ResearchOpen Access04 Feb 2019
Nature Communications

Volume: 10, P: 1-14
Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

Cardiomyocytes generated from induced pluripotent cells hold great promise for understanding and treating heart disease. William Pu and his colleagues apply new technologies for studying such cardiomyocytes from patients with Barth syndrome to explore how the mitochondrial defects characteristic of this syndrome lead to heart dysfunction.

Gang Wang
Megan L McCain
William T Pu
Research11 May 2014
Nature Medicine

Volume: 20, P: 616-623
Cardiac aid to the injured but not the elderly?

A genetic lineage-tracing study provides evidence that adult progenitor cells repopulate the cardiomyocyte pool in diseased hearts, but not during normal aging (pages 970–974). These stem cells could become the basis for innovative ways to treat or prevent heart failure.

Charles E Murry
News & Views01 Aug 2007
Nature Medicine

Volume: 13, P: 901-902
rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice

Paul Gregorevic
James M Allen
Jeffrey S Chamberlain
Research02 Jul 2006
Nature Medicine

Volume: 12, P: 787-789
TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes

Mutations in the gene HADHA result in mitochondrial tri-functional protein (MTP) deficiency and can result in sudden infant death syndrome for which there is no treatment. Here the authors show that the MTP deficient pathology in human cardiomyocytes leads to an abnormal cardiolipin pattern and suggests that cardiolipin affecting compounds may serve as a potential therapy.

Jason W. Miklas
Elisa Clark
Hannele Ruohola-Baker
ResearchOpen Access11 Oct 2019
Nature Communications

Volume: 10, P: 1-21
Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts

A guinea-pig model of cardiac injury is used to show that human embryonic stem-cell-derived cardiomyocyte grafts can electrically integrate into the injured heart, improving mechanical function and reducing spontaneous and induced ventricular tachycardia; this is a major step towards clinical adoption of cell replacement therapies for cardiovascular diseases using human cardiomyocytes.

Yuji Shiba
Sarah Fernandes
Michael A. Laflamme
Research05 Aug 2012
Nature

Volume: 489, P: 322-325
Policy: Global standards for stem-cell research

New guidelines from the International Society for Stem Cell Research offer a model for self-regulation in contentious areas, write Jonathan Kimmelman and colleagues.

Jonathan Kimmelman
Insoo Hyun
George Q. Daley
Comments & Opinion12 May 2016
Nature

Volume: 533, P: 311-313
Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells

Cellular reprogramming is used to pinpoint the genetic abnormalities in a blood cancer caused by a large chromosomal deletion.

Andriana G Kotini
Chan-Jung Chang
Eirini P Papapetrou
Research23 Mar 2015
Nature Biotechnology

Volume: 33, P: 646-655
Hallmarks of cardiac regeneration

Despite substantial advances, bona fide regeneration of the damaged human heart is still an unmet ambition. By extracting our current knowledge from developmental biology, animal models of heart regeneration, and clinical observations, we propose five hallmarks of cardiac regeneration and suggest a holistic approach to reconstituting human heart function.

Alessandro Bertero
Charles E. Murry
Comments & Opinion06 Sept 2018
Nature Reviews Cardiology

Volume: 15, P: 579-580
Sustained miRNA release regenerates the heart

Prolonged local delivery, via an injectable hydrogel, of a miRNA known to induce cardiomyocyte proliferation stimulates the recovery of mice from myocardial infarction.

Katie A. Mitzelfelt
Charles E. Murry
News & Views27 Nov 2017
Nature Biomedical Engineering

Volume: 1, P: 931-933
Response to Cardiac regeneration validated

Anna V Naumova
Michel Modo
Charles E Murry
Correspondence09 Jun 2015
Nature Biotechnology

Volume: 33, P: 587
Author Correction: TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes

Jason W. Miklas
Elisa Clark
Hannele Ruohola-Baker
Amendments and CorrectionsOpen Access08 May 2020
Nature Communications

Volume: 11, P: 1
Regenerating the field of cardiovascular cell therapy

Chien et al. reflect on lessons learned following the recent announcement that 31 papers from the Anversa laboratory on cardiac cell therapy are being retracted.

Kenneth R. Chien
Jonas Frisén
Irving L. Weissman
Reviews18 Feb 2019
Nature Biotechnology

Volume: 37, P: 232-237
Selective repression of myoD transcription by v-Myc prevents terminal differentiation of quail embryo myoblasts transformed by the MC29 strain of avian myelocytomatosis virus

Severina A La Rocca
Serena Vannucchi
Franco Tatò
Research09 Jul 2002
Oncogene

Volume: 21, P: 4838-4842
Clinical imaging in regenerative medicine

Clinical imaging is indispensable in cell therapy to monitor tissue repair and the fate of transplanted cells.

Anna V Naumova
Michel Modo
Joseph A Frank
Reviews05 Aug 2014
Nature Biotechnology

Volume: 32, P: 804-818
Heart regeneration

Michael A. Laflamme
Charles E. Murry
Reviews18 May 2011
Nature

Volume: 473, P: 326-335
Regenerating the heart

Michael A Laflamme
Charles E Murry
Reviews01 Jul 2005
Nature Biotechnology

Volume: 23, P: 845-856
Engineered tissue vascularization and engraftment depends on host model

Eileen L. Brady
Olivia Prado
Kelly R. Stevens
ResearchOpen Access03 Feb 2023
Scientific Reports

Volume: 13, P: 1-12
Polarization sensitive optical coherence tomography with single input for imaging depth-resolved collagen organizations

Discrete differential geometry-based polarization tracing method enables PSOCT imaging of depth-resolved collagen organizations.

Peijun Tang
Mitchell A. Kirby
Ruikang K. Wang
ResearchOpen Access24 Nov 2021
Light: Science & Applications

Volume: 10, P: 1-12
Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells

Different concentrations of activin A and BMP4 are used to polarize stem cells into mesodermal subtypes that reflect mid-primitive-streak cardiogenic mesoderm and posterior-primitive-streak hemogenic mesoderm.

Nathan J Palpant
Lil Pabon
Charles E Murry
Protocols01 Dec 2016
Nature Protocols

Volume: 12, P: 15-31
Selective control of endothelial cell proliferation with a synthetic dimerizer of FGF receptor-1

Marilyn B Nourse
Marsha W Rolle
Charles E Murry
Research18 Jun 2007
Laboratory Investigation

Volume: 87, P: 828-835

Search

Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts

Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias

Human embryonic stem cell–derived cardiomyocytes restore function in infarcted hearts of non-human primates

Epicardial cells derived from human embryonic stem cells augment cardiomyocyte-driven heart regeneration

Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory

Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine

Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies

Erratum: Human embryonic stem cell–derived cardiomyocytes restore function in infarcted hearts of non-human primates

Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts

The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy

Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts

Reprogramming the injured heart

Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

Cardiac aid to the injured but not the elderly?

rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice

TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes

Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts

Policy: Global standards for stem-cell research

Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells

Hallmarks of cardiac regeneration

Sustained miRNA release regenerates the heart

Response to Cardiac regeneration validated

Author Correction: TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes

Regenerating the field of cardiovascular cell therapy

Selective repression of myoD transcription by v-Myc prevents terminal differentiation of quail embryo myoblasts transformed by the MC29 strain of avian myelocytomatosis virus

Clinical imaging in regenerative medicine

Heart regeneration

Regenerating the heart

Engineered tissue vascularization and engraftment depends on host model

Polarization sensitive optical coherence tomography with single input for imaging depth-resolved collagen organizations

Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells

Selective control of endothelial cell proliferation with a synthetic dimerizer of FGF receptor-1

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