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Showing 1–8 of 8 results
Advanced filters: Author: Charles E. Vejnar Clear advanced filters

  • PAM requirement is a constraint for genome editing but this has been circumvented by engineered Cas9 nucleases as SpG and SpRY recognizing minimal PAM sequences. Here, the authors validate and optimize SpG and SpRY in vivo expanding the targeting landscape in animals.

    • Jeremy Vicencio
    • Carlos Sánchez-Bolaños
    • Miguel A. Moreno-Mateos
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • The cis-regulatory elements encoded in the sequence and structure of mRNAs determine their translational output. Here the authors develop NaP-TRAP, an assay to measure translation in a frame-specific manner, revealing dynamic regulatory elements in zebrafish embryos and HEK293T cells.

    • Ethan C. Strayer
    • Srikar Krishna
    • Antonio J. Giraldez
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • The authors show that post-transcriptional regulation of the cilia-driven leftward flow target dand5 is central to symmetry breakage in frog, fish and mouse and is mediated by a 139 nt Bicc1 responsive element in the dand5 3′UTR, and they present evidence that Pkd2 regulates this Bicc1/dand5 module.

    • Markus Maerker
    • Maike Getwan
    • Axel Schweickert
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Characterization of mRNA structure during the zebrafish maternal-to-zygotic transition identifies the ribosome as a major RNA structure remodeler in vivo and reveals that structural dynamics can affect gene expression, partly by modulating miRNA activity.

    • Jean-Denis Beaudoin
    • Eva Maria Novoa
    • Antonio J. Giraldez
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 677-686

  • The RNA-element selection assay (RESA) probes regulatory elements in vivo and identifies protein binding partners and the nucleotides that contribute most to the regulation.

    • Valeria Yartseva
    • Carter M Takacs
    • Antonio J Giraldez
    Research
    Nature Methods
    Volume: 14, P: 201-207