This paper reports an NMR approach that enables the three-dimensional movement of two linked RNA helices to be followed for a period up to milliseconds. The two helices move in a highly correlated manner, demonstrating both twisting and bending. Results with different liganded conformations demonstrate that the motions of the unstructured RNA maps out positions within the dynamic envelope described by the bound structures.
- Qi Zhang
- Andrew C. Stelzer
- Hashim M. Al-Hashimi
