Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–9 of 9 results
Advanced filters: Author: Charles-Hugues Lardeau Clear advanced filters

  • Identifying active compounds for a target is time- and resource-intensive. Here, the authors show that deep learning models trained on Cell Painting and single-point activity data, can reliably predict compound activity across diverse targets while maintaining high hit rates and scaffold diversity.

    • Johan Fredin Haslum
    • Charles-Hugues Lardeau
    • Erik Müllers
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • Our understanding of the mechanisms of drug interactions remains limited. Here the authors introduce a framework to study how complex cellular perturbations induced by different drugs affect each other in morphological feature space.

    • Michael Caldera
    • Felix Müller
    • Jörg Menche
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • A set of CRISPR–Cas9-based genetic screens in a haploid human cell line identifies more than 200 gene–drug associations involving solute carriers (SLCs), transporters important for the uptake and activity of cytotoxic drugs.

    • Enrico Girardi
    • Adrián César-Razquin
    • Giulio Superti-Furga
    Research
    Nature Chemical Biology
    Volume: 16, P: 469-478

  • The use of a refined chemical library called the CeMM library of unique drugs (CLOUD) identified a synergistic interaction between flutamide and phenprocoumon in decreasing the growth of prostate cancer cells by regulating androgen receptor stability.

    • Marco P Licciardello
    • Anna Ringler
    • Stefan Kubicek
    Research
    Nature Chemical Biology
    Volume: 13, P: 771-778

  • A high-content screening platform that measures the immunological potential of small-molecule and biologic drugs by computationally determining changes in the physical interactions among peripheral mononuclear leukocytes revealed known immunomodulators and also approved drugs as regulators of unexpected targets, including MST1R.

    • Gregory I Vladimer
    • Berend Snijder
    • Giulio Superti-Furga
    Research
    Nature Chemical Biology
    Volume: 13, P: 681-690

  • We provide an updated protocol for image-based profiling with Cell Painting. A detailed procedure, with standardized conditions for the assay, is presented, along with a comprehensive description of parameters to be considered when optimizing the assay.

    • Beth A. Cimini
    • Srinivas Niranj Chandrasekaran
    • Anne E. Carpenter
    Protocols
    Nature Protocols
    Volume: 18, P: 1981-2013