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Showing 1–3 of 3 results
Advanced filters: Author: Charlotte Gehin Clear advanced filters

  • The Bcr-Abl tyrosine kinases p210 and p190 are linked to different leukemias and differ by the Dbl homology (DH) and Pleckstrin-homology (PH) domains. Here the authors characterize structures of the Bcr-Abl p210 DH and PH domains and find that the PH domain is important for the cellular localization and signaling network of p210.

    • Sina Reckel
    • Charlotte Gehin
    • Oliver Hantschel
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • Little is known about how individual cells within a group of cells exposed to the same external signals can produce a specific individual response to their local microenvironment; a quantitative analysis of cell crowding reveals that single cells can autonomously sense local crowding though their ability to spread and activate focal adhesion kinase (FAK), which ultimately results in changes in cellular lipid composition.

    • Mathieu Frechin
    • Thomas Stoeger
    • Lucas Pelkmans
    Research
    Nature
    Volume: 523, P: 88-91