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Showing 1–9 of 9 results

Advanced filters: Author: Charlotte J. Imianowski Clear advanced filters

Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy

One of three back-to-back papers to show dosage of BACH2 can modulate T cell differentiation and function and how we might apply this to enhance chimeric antigen receptor T cell therapies for cancer.

Alberto G. Conti
Alexander C. Evans
Rahul Roychoudhuri
ResearchOpen Access16 Jan 2026
Nature Immunology

P: 1-16
Regulatory T cells in the tumour microenvironment

This Review by Imianowski et al. outlines the various contributions that regulatory T cells, present in the tumour microenvironment, make towards tumour progression and highlight the ways in which they represent attractive next-generation immunotherapeutic targets.

Charlotte J. Imianowski
Qiang Chen
Dario A. A. Vignali
Reviews10 Jun 2025
Nature Reviews Cancer

Volume: 25, P: 703-722
A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by T_reg cells

Shared synteny guides loss-of-function analysis of human enhancer homologues in mice, identifying a distal enhancer at the autoimmune and allergic disease risk locus at chromosome 11q13.5 whose function in regulatory T cells provides a mechanistic basis for its role in disease.

Rabab Nasrallah
Charlotte J. Imianowski
Rahul Roychoudhuri
Research13 May 2020
Nature

Volume: 583, P: 447-452
Perturbing local steroidogenesis to improve breast cancer immunity

Researchers show inhibiting immune cell steroidogenesis enhances anti-tumour immunity in triple-negative breast cancer. Posaconazole showed promise in a humanised mouse model.

Qiuchen Zhao
Jhuma Pramanik
Bidesh Mahata
ResearchOpen Access26 Apr 2025
Nature Communications

Volume: 16, P: 1-18
Aspirin prevents metastasis by limiting platelet TXA₂ suppression of T cell immunity

Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A₂, thereby enhancing the immune response against metastasis.

Jie Yang
Yumi Yamashita-Kanemaru
Rahul Roychoudhuri
ResearchOpen Access05 Mar 2025
Nature

Volume: 640, P: 1052-1061
Gut microbiota-derived hexa-acylated lipopolysaccharides enhance cancer immunotherapy responses

Hexa-acylated lipopolysaccharides from the gut microbiota are associated with efficacy in patients with cancer receiving anti-PD-1 and stimulate host immune activation for enhanced anti-tumour immunity in mouse models.

Puspendu Sardar
Benjamin S. Beresford-Jones
Virginia A. Pedicord
ResearchOpen Access10 Feb 2025
Nature Microbiology

Volume: 10, P: 795-807
Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis

Here Ramanan and colleagues provide an analysis of mammary T cells during late pregnancy and lactation. This revealed an increase in intraepithelial lymphocytes in the lactating mammary gland, which was driven by thymic and intestinal inputs and was sensitive to changes in the microbiota

Abigail Jaquish
Eleni Phung
Deepshika Ramanan
Research29 Jul 2025
Nature Immunology

Volume: 26, P: 1411-1422
Smad4 and TGFβ1 dependent gene expression signatures in conditional intestinal adenoma, organoids and colorectal cancer

Mirvat Surakhy
Julia Matheson
Andrew Bassim Hassan
ResearchOpen Access10 May 2025
Scientific Reports

Volume: 15, P: 1-19
A cell-based bioluminescence assay reveals dose-dependent and contextual repression of AP-1-driven gene expression by BACH2

Panagiota Vardaka
Teresa Lozano
Rahul Roychoudhuri
ResearchOpen Access03 Nov 2020
Scientific Reports

Volume: 10, P: 1-10