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Showing 1–15 of 15 results
Advanced filters: Author: Chase P. Broedersz Clear advanced filters

  • Chromosomes interact with the cell environment through their interface. Here, the authors use Atomic Force Microscopy to probe the interface and local micromechanics of the chromatin network of native human mitotic chromosomes.

    • Andrea Ridolfi
    • Hannes Witt
    • Gijs J. L. Wuite
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10

  • The physical mechanisms that govern chromosomal viscoelasticity remain elusive. Here the authors combine single-chromosome manipulation and computational methods to show that their collective properties are controlled by the physico-chemical environment.

    • Hannes Witt
    • Janni Harju
    • Gijs J. L. Wuite
    ResearchOpen Access
    Nature Materials
    Volume: 23, P: 1556-1562

  • A paper published in 1997 brought the thermodynamics of the nineteenth century into the twenty-first century — expanding the physics of transformations involved in the operation of steam engines to the realm of molecular motors.

    • Chase P. Broedersz
    • Pierre Ronceray
    News & Views
    Nature
    Volume: 604, P: 46-47

  • Bacterial chromosomes segregate while undergoing replication. Here the authors show that such concurrent replication and segregation cannot be achieved by passive entropic forces alone, and that loop-extruders could be sufficient to explain segregation.

    • Janni Harju
    • Muriel C. F. van Teeseling
    • Chase P. Broedersz
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • A method that uses a combination of optical trapping, fluorescence microscopy and microfluidics to analyse the internal structure of chromosomes shows that there is a distinct nonlinear stiffening of the chromosome in response to tension.

    • Anna E. C. Meijering
    • Kata Sarlós
    • Gijs J. L. Wuite
    ResearchOpen Access
    Nature
    Volume: 605, P: 545-550

  • The order and variability of bacterial chromosome organization, contained within the distribution of chromosome conformations, are unclear. Here, the authors develop a fully data-driven maximum entropy approach to extract single-cell 3D chromosome conformations from Hi-C experiments on the model organism Caulobacter crescentus.

    • Joris J. B. Messelink
    • Muriel C. F. van Teeseling
    • Chase P. Broedersz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • The existence of multicellular systems relies on coordinated cell motion in three dimensions. Here, cell migration in rotating spherical tissues is shown to exhibit a collective mode with a single-wavelength velocity wave, which arises from the effect of curvature on the flocking behavior of cells on a spherical surface.

    • Tom Brandstätter
    • David B. Brückner
    • Chase P. Broedersz
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Three-dimensional printed protein-based robotic structures are actuated by exoskeleton-like coats of molecular motor assemblies upon the spatially targeted release of chemical fuel, resulting in micrometre-scale shape-morphing activity.

    • Haiyang Jia
    • Johannes Flommersfeld
    • Petra Schwille
    ResearchOpen Access
    Nature Materials
    Volume: 21, P: 703-709

  • Two-state micropatterns offer a unique platform to study cell migration. An equation of motion is inferred from a large ensemble of trajectories, revealing key differences in the nonlinear dynamics of healthy and cancerous cells.

    • David B. Brückner
    • Alexandra Fink
    • Chase P. Broedersz
    Research
    Nature Physics
    Volume: 15, P: 595-601

  • A tracking-free approach by Gnesotto et al. is developed to distinguish active and thermal fluctuations in microscopy data of non-equilibrium systems such as cell membranes. The method relies on a dimensional reduction scheme revealing a hierarchy of the most dissipative dynamical components.

    • Federico S. Gnesotto
    • Grzegorz Gradziuk
    • Chase P. Broedersz
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • Cells in the connective tissue are surrounded by a heterogeneous network of biopolymers. Here, the authors investigate how such heterogeneity affects cellular mechanosensing by simulating the deformation response of experimental and modelled biopolymer networks to locally applied forces.

    • Farzan Beroz
    • Louise M. Jawerth
    • Ned S. Wingreen
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • In fibre networks, mechanical stability relies on the fibres’ bending resistance—in contrast to rubbers, where entropic stretching is the key. The extent to which the mechanics of fibre networks is controlled by bending is, however, an open question. The study of a general lattice-based model of fibrous networks now reveals two rigidity critical points, one of which controls a rich crossover from stretching-dominated to bending-dominated behaviour.

    • Chase P. Broedersz
    • Xiaoming Mao
    • Frederick C. MacKintosh
    Research
    Nature Physics
    Volume: 7, P: 983-988