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Showing 1–7 of 7 results
Advanced filters: Author: Chay T. Kuo Clear advanced filters

  • Infection of a cell with influenza B virus (IBV) often results in cell death and the role of surviving cells in pathogenesis is unclear. Here, Dumm et al. generate a recombinant IBV that activates a host-cell reporter to permanently label infected cells, and show that surviving cells are important to preserve epithelial barrier function.

    • Rebekah E. Dumm
    • Jessica K. Fiege
    • Nicholas S. Heaton
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Immature dentate gyrus neurons are highly excitable and are thought to be more responsive to afferent activity than mature neurons. Here, the authors find stimulation of the entorhinal cortex paradoxically generates spiking in mature rather than immature neurons due to low synaptic connectivity of immature cells.

    • Cristina V. Dieni
    • Roberto Panichi
    • Linda Overstreet-Wadiche
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Multiciliated ependymal cells (ECs) in the mammalian brain are glial cells facilitating cerebral spinal fluid movement. This study describes an inherent cellular plasticity of ECs as maintained by Foxj1 and IKK2 signaling, and shows resulting hydrocephalus when EC de-differentiation is triggered.

    • Khadar Abdi
    • Chun-Hsiang Lai
    • Chay T. Kuo
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • This study describes a novel population of cholinergic neurons in the adult subependymal zone (SEZ) of mouse that modulates neural progenitor proliferation. These ChAT+ neurons in the SEZ display neuronal activity-dependent release of acetylcholine locally and stimulate neurogenesis accordingly.

    • Patricia Paez-Gonzalez
    • Brent Asrican
    • Chay T Kuo
    Research
    Nature Neuroscience
    Volume: 17, P: 934-942

  • Asymmetric cell division is a fundamental process by which cells give rise to progenies with different fates. Although this mechanism is well studied in the worm and fly, mammalian asymmetric cell division is poorly understood. The finding that Gβγ and AGS3 can control mitotic spindle orientation and progenitor cell fates during mouse cortical development suggests evolutionarily conserved roles in asymmetric cell division.

    • Chay T. Kuo
    • Yuh-Nung Jan
    News & Views
    Nature Cell Biology
    Volume: 7, P: 858-859