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Structural basis for sequestration and autoinhibition of cGAS by chromatin

Biochemical and structural analyses show how tethering of the nucleotidyltransferase cGAS to chromatin prevents autoimmune recognition of nuclear DNA.

Sebastian Michalski
Carina C. de Oliveira Mann
Karl-Peter Hopfner
Research10 Sept 2020
Nature

Volume: 587, P: 678-682
Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation

N-acetylglucosamine kinase catalyses the phosphorylation of muramyl dipeptide and is thus essential for its recognition and immunostimulatory activity in human and mouse cells.

Che A. Stafford
Alicia-Marie Gassauer
Veit Hornung
ResearchOpen Access24 Aug 2022
Nature

Volume: 609, P: 590-596
Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology

Protein ubiquitylation is often studied by proteomics but how data independent acquisition (DIA) may advance these studies remains to be explored. Here, the authors show that DIA improves ubiquitylation site identification and quantification, enabling them to characterize the circadian ubiquitinome in human cells.

Fynn M. Hansen
Maria C. Tanzer
Matthias Mann
ResearchOpen Access11 Jan 2021
Nature Communications

Volume: 12, P: 1-13
Phosphoproteome profiling uncovers a key role for CDKs in TNF signaling

Tumor necrosis factor (TNF) has various effects on phosphorylation-mediated cellular signaling. Combining phosphoproteomics, subcellular localization analyses and kinase inhibitor assays, the authors provide systems level insights into TNF signaling and identify modulators of TNF-induced cell death.

Maria C. Tanzer
Isabell Bludau
Matthias Mann
ResearchOpen Access18 Oct 2021
Nature Communications

Volume: 12, P: 1-15
A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

Receptor Interacting Protein Kinase 2 (RIPK2) mediates innate immune signalling in response to intracellular pathogens, but its aberrant activation contributes to autoimmune pathologies. Here Nachbur et al.describe a RIPK2 inhibitor that is effective in a mouse model of multiple sclerosis.

Ueli Nachbur
Che A. Stafford
John Silke
Research17 Mar 2015
Nature Communications

Volume: 6, P: 1-13
Seasonality, food security, diet quality and nutritional status in urban poor adolescents in Malaysia

Janice Ee Fang Tay
Serene En Hui Tung
Choon Hui Tan
ResearchOpen Access12 Sept 2023
Scientific Reports

Volume: 13, P: 1-11

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Structural basis for sequestration and autoinhibition of cGAS by chromatin

Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation

Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology

Phosphoproteome profiling uncovers a key role for CDKs in TNF signaling

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

Seasonality, food security, diet quality and nutritional status in urban poor adolescents in Malaysia

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