Sestrins are conserved stress-inducible metabolic regulators implicated in the prevention of agerelated diseases. Here, Kim et al.report the crystal structure of human Sestrin2 and propose a molecular mechanism for how Sestrin2 functions to prevent ROS accumulation and inhibit mTORC1 activity.
- Hanseong Kim
- Sojin An
- Uhn-Soo Cho