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Advanced filters: Author: Chen-Chia Lo Clear advanced filters

  • Here the authors show TERRA R-loops recruit the endonuclease XPF to telomeres, leading to DNA double-strand breaks to activate break-induced telomere synthesis at telomeres that utilize the alternative lengthening of telomeres (ALT) pathway to extend their telomeres independent of telomerase.

    • Chia-Yu Guh
    • Hong-Jhih Shen
    • Hsueh-Ping Catherine Chu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19