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Dynamics of yeast histone H2A and H2B phosphorylation in response to a double-strand break

Histone H2A is rapidly phosphorylated to γH2AX at the site of DNA double-strand breaks (DSBs). A new, genome-wide analysis in Saccharomyces cerevisiae reports a second histone phosphorylation, γH2B, and examines the modification kinetics and chromosomal distribution of both γH2AX and γH2B and their propagation from DSBs to other genomic loci.

Cheng-Sheng Lee
Kihoon Lee
James E Haber
Research15 Dec 2013
Nature Structural & Molecular Biology

Volume: 21, P: 103-109
BCR selection and affinity maturation in Peyer’s patch germinal centres

An analysis of the immunoglobulin repertoire of B cells in Peyer’s patch germinal centres in mice provides evidence for the selection of B cell receptor clonotypes by gut antigens and antigen-driven affinity maturation.

Huan Chen
Yuxiang Zhang
Frederick W. Alt
Research06 May 2020
Nature

Volume: 582, P: 421-425
Loop extrusion mediates physiological Igh locus contraction for RAG scanning

Long-distance V(D)J recombination is facilitated by contraction of the Igh locus and linear RAG scanning along chromatin, both driven by cohesin-mediated loop extrusion, which allows recombination of widely separated gene segments to occur.

Hai-Qiang Dai
Hongli Hu
Frederick W. Alt
Research13 Jan 2021
Nature

Volume: 590, P: 338-343
Evaluation of performance of generative large language models for stroke care

John Tayu Lee
Vincent Cheng-Sheng Li
Rifat Atun
ResearchOpen Access29 Jul 2025
npj Digital Medicine

Volume: 8, P: 1-8
The correlation between plasma brain-derived neurotrophic factor and cognitive function in bipolar disorder is modulated by the BDNF Val66Met polymorphism

Sheng-Yu Lee
Tzu-Yun Wang
Cheng-Sheng Chen
ResearchOpen Access01 Dec 2016
Scientific Reports

Volume: 6, P: 1-8
Genetic surveillance reveals low but sustained malaria transmission with clonal replacement in Sao Tome and Principe

Chen et al. conduct a genome-wide analysis of malaria parasites collected over 7 years from Sao Tome and Principe. The study reveals low genetic diversity, clonal turnover, importation, and limited recombination. There is a need for targeted strategies such as stopping importation and improving detection to halt transmission to achieve total elimination.

Ying‑An Chen
Peng-Yin Ng
Hsiao-Han Chang
ResearchOpen Access27 May 2025
Communications Medicine

Volume: 5, P: 1-12
Effect of a novel telehealth device for dietary cognitive behavioral intervention in overweight or obesity care

Yi-Ya Fang
Jia-In Lee
Cheng-Sheng Chen
ResearchOpen Access20 Apr 2023
Scientific Reports

Volume: 13, P: 1-9

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Dynamics of yeast histone H2A and H2B phosphorylation in response to a double-strand break

BCR selection and affinity maturation in Peyer’s patch germinal centres

Loop extrusion mediates physiological Igh locus contraction for RAG scanning

Evaluation of performance of generative large language models for stroke care

The correlation between plasma brain-derived neurotrophic factor and cognitive function in bipolar disorder is modulated by the BDNF Val66Met polymorphism

Genetic surveillance reveals low but sustained malaria transmission with clonal replacement in Sao Tome and Principe

Effect of a novel telehealth device for dietary cognitive behavioral intervention in overweight or obesity care

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Dynamics of yeast histone H2A and H2B phosphorylation in response to a double-strand break

BCR selection and affinity maturation in Peyer’s patch germinal centres

Loop extrusion mediates physiological Igh locus contraction for RAG scanning

Evaluation of performance of generative large language models for stroke care

The correlation between plasma brain-derived neurotrophic factor and cognitive function in bipolar disorder is modulated by the BDNF Val66Met polymorphism

Genetic surveillance reveals low but sustained malaria transmission with clonal replacement in Sao Tome and Principe

Effect of a novel telehealth device for dietary cognitive behavioral intervention in overweight or obesity care

Search

Quick links