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A germline-to-soma signal triggers an age-related decline of mitochondrial stress response

As worms reach adulthood and commit to reproduction, their ability to respond to mitochondrial stress diminishes. Here, Zhou et al. identify a germline-to-soma Hedgehog-like signal that suppresses UPR^mt, prioritizing reproduction over somatic maintenance.

Liankui Zhou
Liu Jiang
Ying Liu
ResearchOpen Access08 Oct 2024
Nature Communications

Volume: 15, P: 1-19
N6-methyldeoxyadenine is a transgenerational epigenetic signal for mitochondrial stress adaptation

Ma et al. show that exposure of Caenorhabditis elegans to mitochondrial stress triggers stress adaptation in offspring, which is mediated by 6mA DNA modification at mitochondrial unfolded-protein-response genes.

Chengchuan Ma
Rong Niu
Ying Liu
Research03 Dec 2018
Nature Cell Biology

Volume: 21, P: 319-327
A novel N⁶-Deoxyadenine methyltransferase METL-9 modulates C. elegans immunity via dichotomous mechanisms

Chengchuan Ma
Tingling Xue
Ying Liu
ResearchOpen Access05 Jun 2023
Cell Research

Volume: 33, P: 628-639