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Showing 1–7 of 7 results
Advanced filters: Author: Chenghai Lu Clear advanced filters

  • β-Branched aromatic α-amino acids are valuable building blocks in natural products and pharmaceutically active compounds, but their synthesis is challenging due to the presence of two stereocenters. Here, the authors design phenylalanine ammonia lyases variants for the direct asymmetric synthesis of β-branched aromatic α-amino acids and reveal the reasons for enzyme’s inability to accept β-methyl cinnamic acid.

    • Chenghai Sun
    • Gen Lu
    • Uwe T. Bornscheuer
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • The study identifies an optimal pore size of ~7 μm in electrified membranes for contaminant valorization. This size maximizes reaction efficiency by balancing mass transfer and current distribution. The finding provides a key design principle for sustainable water treatment technologies.

    • Yuyang Kang
    • Zhenao Gu
    • Jiuhui Qu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • The hexahydropyrrolo[2, 3-b]indole (HPI) framework is found in many natural products. Here, the authors discover a P450 enzyme and develop a whole-cell biocatalysis system that produces the HPI naseseazine C (NAS-C) and 30 NAS-C analogs, several of which show neuroprotective properties.

    • Wenya Tian
    • Chenghai Sun
    • Xudong Qu
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9

  • Innovations in device design, material fabrication and deep learning are described, leading to a wearable ultrasound transducer capable of dynamic cardiac imaging in various environments and under different conditions.

    • Hongjie Hu
    • Hao Huang
    • Sheng Xu
    ResearchOpen Access
    Nature
    Volume: 613, P: 667-675

  • This overview of the ENCODE project outlines the data accumulated so far, revealing that 80% of the human genome now has at least one biochemical function assigned to it; the newly identified functional elements should aid the interpretation of results of genome-wide association studies, as many correspond to sites of association with human disease.

    • Ian Dunham
    • Anshul Kundaje
    • Ewan Birney
    ResearchOpen Access
    Nature
    Volume: 489, P: 57-74

  • Uniform processing and detailed annotation of human, worm and fly RNA-sequencing data reveal ancient, conserved features of the transcriptome, shared co-expression modules (many enriched in developmental genes), matched expression patterns across development and similar extent of non-canonical, non-coding transcription; furthermore, the data are used to create a single, universal model to predict gene-expression levels for all three organisms from chromatin features at the promoter.

    • Mark B. Gerstein
    • Joel Rozowsky
    • Robert Waterston
    ResearchOpen Access
    Nature
    Volume: 512, P: 445-448