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Showing 1–4 of 4 results
Advanced filters: Author: Chengkun Xing Clear advanced filters

  • Insertion of a long DNA sequence into the host genome is challenging in mammalian cells. Here, the authors develop a recombinase (Redα/β)-enhanced DNA integration approach, which enables efficient and precise kilobase-scale DNA insertion in both primary cells and mouse embryos.

    • Wenqing Li
    • Senquan Liu
    • Jianqiang Bao
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-24

  • EviDTI introduces an evidential deep learning framework for drug-target interaction prediction, providing reliable uncertainty estimates to prioritize high-confidence predictions. It identifies potential tyrosine kinase modulators, thereby improving the efficiency of drug discovery.

    • Yanpeng Zhao
    • Yuting Xing
    • Xiaochen Bo
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • The assembly of oligopeptide and polypeptide molecules can reconstruct various ordered advanced structures. Here the authors develop a “molecular velcro”-inspired amphiphilic supramolecular co-assembly strategy, which improves the mechanical strength and cartilaginous regeneration efficiency through conformation transition.

    • Chengkun Zhao
    • Xing Li
    • Yong Sun
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Spin ice compounds are typically insulating and introducing carriers can destroy the spin ice state, making integration into electronic devices problematic. Here the authors report a transport response to an ice-rule-breaking transition in a heterostructure of a pyrochlore spin ice and a nonmagnetic metal.

    • Han Zhang
    • Chengkun Xing
    • Jian Liu
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-7