PROTACs can directly and selectively degrade proteins, which opens promising applications in the design of novel drugs, but designing effective PROTACs is a hard challenge due to the complexity of pharmacokinetics. Zheng et al. use a deep generative model to create likely candidates and screen them further to identify a novel BRD4-degrading PROTAC.
- Shuangjia Zheng
- Youhai Tan
- Yuedong Yang
