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Plasma proteomic profiles identify biomarkers predicting Crohn’s disease up to 16 years before onset

Tools to identify who will develop Crohn’s disease in the future are limited. Here, the authors develop and validate a proteomics-based model that predicts disease onset up to 16 years before clinical diagnosis.

Jing Feng
Shuo Chen
Hao Chen
ResearchOpen Access12 Dec 2025
Nature Communications

Volume: 16, P: 1-13
Multi-branch low-light image iterative enhancement network

Yiwen Dou
Yiting Gao
Chenhao Zeng
ResearchOpen Access03 Dec 2025
Scientific Reports

Volume: 15, P: 1-17
Targeting ALK averts ribonuclease 1-induced immunosuppression and enhances antitumor immunity in hepatocellular carcinoma

Immune checkpoint inhibitors have now been approved for the treatment of advanced hepatocellular carcinoma (HCC), however only a minority of patients appear to benefit. Here the authors report that RNase1 levels predict response to nivolumab (anti-PD1) in patients with HCC and that RNase 1 overexpression correlates with an immunosuppressive tumor microenvironment in HCC preclinical models.

Chunxiao Liu
Chenhao Zhou
Mien-Chie Hung
ResearchOpen Access02 Feb 2024
Nature Communications

Volume: 15, P: 1-18
Soliton-dependent plasmon reflection at bilayer graphene domain walls

2D surface plasmon polaritons are used to probe the domain-wall solitons in bilayer graphene; near-field infrared nanoscopy reveals various domain-wall structures in mechanically exfoliated graphene bilayers.

Lili Jiang
Zhiwen Shi
Feng Wang
Research30 May 2016
Nature Materials

Volume: 15, P: 840-844
Disulfidptosis links the pathophysiology of ulcerative colitis and immune infiltration in colon adenocarcinoma

Chenhao Jiang
Teng Yue
Qianqian Li
ResearchOpen Access13 Feb 2025
Scientific Reports

Volume: 15, P: 1-17
Topological valley transport at bilayer graphene domain walls

The bandgap of bilayer graphene can be tuned with an electric field and topological valley polarized modes have been predicted to exist at its domain boundaries; here, near-field infrared imaging and low-temperature transport measurements reveal such modes in gapped bilayer graphene.

Long Ju
Zhiwen Shi
Feng Wang
Research22 Apr 2015
Nature

Volume: 520, P: 650-655

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Plasma proteomic profiles identify biomarkers predicting Crohn’s disease up to 16 years before onset

Multi-branch low-light image iterative enhancement network

Targeting ALK averts ribonuclease 1-induced immunosuppression and enhances antitumor immunity in hepatocellular carcinoma

Soliton-dependent plasmon reflection at bilayer graphene domain walls

Disulfidptosis links the pathophysiology of ulcerative colitis and immune infiltration in colon adenocarcinoma

Topological valley transport at bilayer graphene domain walls

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