Behçet’s disease (BD) is characterized by polymorphonuclear neutrophils (PMN) and macrophage activation, but their interaction remains elusive. The authors here find PMN exosomes from BD patients are attenuated in suppressing proinflammatory macrophages when cocultured in vitro with the mechanism of decreased miR-122-5p/IRF5/TLR4 signaling and IFN-β autocrine pathway.
- Xin Yu
- Menghao Zhang
- Wenjie Zheng
