The linear-selective allylic addition to carbonyls remains challenging owing to the inversion of the six-membered transition state. Now an enantio- and linear-selective allylic addition to ketimines using reductive cobalt catalysis is reported. The process proceeds via a stereoselective radical pathway, forming homoallylic amino esters with excellent enantioselectivity and broad functional group tolerance.
- Xianqing Wu
- Yue Shi
- Yifeng Chen
