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Showing 1–2 of 2 results
Advanced filters: Author: Chenling Qu Clear advanced filters

  • Vitamin D deficiency was associated with obesity. But their causal relationship is still controversial. CYP27B1 plays a direct role in circulating the concentration of 25(OH)D, which can be used to investigate causal relationships. In this study, allele T of rs10877012 and allele T of rs4646536 in CYP27B1 were family-based linked with both vitamin D deficiency and obesity. In addition, both rs10877012 and rs4646536 were associated with serum 25(OH)D3 levels between siblings but not BMI. Therefore, vitamin D deficiency may be a causal factor of obesity. Maintaining sufficient vitamin D is beneficial to obesity prevention.

    • Songcheng Yu
    • Yinhua Feng
    • Xing Li
    Research
    European Journal of Clinical Nutrition
    Volume: 74, P: 806-810

  • Note:rs3847987 is single nucleotide polymorphism of vitamin D metabolic pathway gene VDR. According to the principle of Mendelian Randomization study, if rs3847987 was associated with vitamin D deficiency as well as hypertention, and the association between vitamin D deficiency and hypertention was observed. Then, it could be come to the conclusion that vitamin D deficiency may be a causal factor of hypertention.

    • Lanxin Bai
    • Chenling Qu
    • Songcheng Yu
    Research
    Hypertension Research
    Volume: 45, P: 1814-1822