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Showing 1–3 of 3 results
Advanced filters: Author: Cheryl D. Zimberlin Clear advanced filters

  • Using the CRISPR/Cas9 system, up to four frequently occurring colorectal cancer mutations were introduced alone or in combination into stem cell organoids derived from human small intestinal or colon tissue, allowing an in-depth investigation of the contribution of these mutations to cancer progression.

    • Jarno Drost
    • Richard H. van Jaarsveld
    • Hans Clevers
    Research
    Nature
    Volume: 521, P: 43-47

  • The anti-apoptotic protein Bcl-2 is selectively expressed in intestinal stem cells (ISCs). Here, the authors show that, in intestinal stem cells, Bcl-2 alleviates apoptotic priming induced by the loss of the tumour suppressor Apc in ISCs and that the absence of Bcl-2 or pharmacological blockade of Bcl-2 can inhibit the intestinal tumorigenesis driven by the Apc-loss.

    • Maartje van der Heijden
    • Cheryl D. Zimberlin
    • Louis Vermeulen
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11