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Showing 1–4 of 4 results
Advanced filters: Author: Cheulhee Jung Clear advanced filters

  • A pair of artificial DNA bases have now been shown to adopt an edge-to-edge geometry in DNA which is similar that found in Watson–Crick base pairing. Aptamers containing these bases have also been shown to bind more strongly to a target than those developed using only the four naturally occurring bases.

    • Cheulhee Jung
    • Andrew D. Ellington
    News & Views
    Nature Chemistry
    Volume: 7, P: 617-619

  • Current approaches for the delivery of CRISPR systems into cells can be hampered by several limitations, including low delivery potential and inefficient genome editing. Here, the authors present Droplet Cell Pincher (DCP), a gene delivery system that combines droplet microfluidics with cell mechanoporation, which attains efficient genome engineering.

    • You-Jeong Kim
    • Dayoung Yun
    • Aram J. Chung
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • Symmetrical protein oligomers perform key structural and catalytic functions in nature, but engineering such oligomers synthetically is challenging. Now, oppositely supercharged synthetic variants of normally monomeric proteins have been shown to assemble via specific, introduced electrostatic contacts into symmetrical, highly well-defined oligomers.

    • Anna J. Simon
    • Yi Zhou
    • Andrew D. Ellington
    Research
    Nature Chemistry
    Volume: 11, P: 204-212