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Showing 1–3 of 3 results
Advanced filters: Author: Chiara Mozzetta Clear advanced filters
  • Repressive histone Lys methyltransferases (KMTs) mediate gene silencing by methylating histone H3 Lys 9 (H3K9), H3K27 and H4K20. Progress has been made in our understanding of the biochemical and functional properties of KMTs, the mechanisms of their recruitment to chromatin and the interplay between them.

    • Chiara Mozzetta
    • Ekaterina Boyarchuk
    • Slimane Ait-Si-Ali
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 499-513
  • Rhabdomyosarcoma (RMS) is the most diffused soft tissue sarcoma in children and adolescents. Herein, the authors identify the m6A machinery and the RNA helicase DDX5 as factors responsible for the increase of a subset of circRNAs in RMS, providing protein and RNA candidates for the study of its tumorigenicity.

    • Dario Dattilo
    • Gaia Di Timoteo
    • Irene Bozzoni
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15
  • Hutchinson-Gilford progeria syndrome is a genetic disease where an aberrant form of Lamin A disrupts chromatin by interfering with lamina associated domains. Here, the authors present the SAMMY-seq, a method for genome-wide characterization of heterochromatin dynamics and detect early stage alterations of heterochromatin structure in progeria primary fibroblasts, accompained by Polycomb dysfunctions.

    • Endre Sebestyén
    • Fabrizia Marullo
    • Chiara Lanzuolo
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16