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Showing 1–3 of 3 results
Advanced filters: Author: Chiara Ninfali Clear advanced filters

  • Following muscle damage, an inflammatory response is associated to activation of satellite cells, which drive muscle repair. Here, the authors show that upregulation of Zeb1 in macrophages and muscle fibres regulates inflammation, and also show a role for Zeb1 in maintenance of satellite cell quiescence.

    • Laura Siles
    • Chiara Ninfali
    • Antonio Postigo
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-18

  • The immune suppression required for the resolution of acute inflammation is characterised by molecular and metabolic reprogramming of myeloid cells. Authors here show that the transcription factor ZEB1 is a key mediator of the pathway governing transition from inflammation to immunosuppression via regulating mitochondrial translation in macrophages.

    • Marlies Cortés
    • Agnese Brischetto
    • Antonio Postigo
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • Accumulation of lipid-laden macrophages in the arterial wall is a critical step in atherosclerosis. Here, the authors show that downregulation of Zeb1 in macrophages promotes lipid accumulation and atherosclerotic plaque formation while its restoration with macrophage-targeted nanoparticles reverses these effects.

    • M. C. Martinez-Campanario
    • Marlies Cortés
    • Antonio Postigo
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21