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PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia

Saliakoura et al. find that PLCγ1 is suppressed in hypoxic KRAS-mutant lung cancer cells, which impairs Ca²⁺ entry into the mitochondria and promotes glycolysis to enhance tumour progression.

Maria Saliakoura
Matteo Rossi Sebastiano
Georgia Konstantinidou
Research19 Oct 2020
Nature Cell Biology

Volume: 22, P: 1382-1395
Hepatitis C virus, non-Hodgkin's lymphomas and hepatocellular carcinoma

S De Vita
V Zagonel
S Franceschi
Research01 Jun 1998
British Journal of Cancer

Volume: 77, P: 2032-2035
A DNA-PK phosphorylation site on MET regulates its signaling interface with the DNA damage response

Jonas P. Koch
Selina M. Roth
Michaela Medová
ResearchOpen Access15 May 2023
Oncogene

Volume: 42, P: 2113-2125
The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer

Maria Saliakoura
Inés Reynoso-Moreno
Georgia Konstantinidou
ResearchOpen Access07 Feb 2020
Oncogene

Volume: 39, P: 2948-2960
Predictors of recurrence of pheochromocytoma and paraganglioma: a multicenter study in Piedmont, Italy

Mirko Parasiliti-Caprino
Barbara Lucatello
Mauro Maccario
Research04 Oct 2019
Hypertension Research

Volume: 43, P: 500-510