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Biogenesis and structure of a type VI secretion baseplate

The cryo-EM structure of the TssKFGE baseplate wedge complex of the type VI secretion system (T6SS) from enteroaggregative Escherichia coli helps to elucidate the molecular architecture of the whole T6SS baseplate, and its assembly and mode of action.

Yassine Cherrak
Chiara Rapisarda
Eric Durand
Research15 Oct 2018
Nature Microbiology

Volume: 3, P: 1404-1416
Bacterial RadA is a DnaB-type helicase interacting with RecA to promote bidirectional D-loop extension

Bacterial homologous recombination involves the actions of RadA and RecA to promote single-stranded DNA integration. Here the authors report the structure of RadA fromStreptococcus pneumoniaeand demonstrate that it acts as a hexameric DnaB-type helicase.

Léa Marie
Chiara Rapisarda
Patrice Polard
ResearchOpen Access31 May 2017
Nature Communications

Volume: 8, P: 1-14
Structural insights into epitope-paratope interactions of a monoclonal antibody targeting CEACAM5-expressing tumors

Cryo-electron microscopy was used to determine the high-resolution structure of the antigen-binding fragment of tusamitamab bound to the A3-B3 domains of CEACAM5. The conformational constraints discovered in this study may inform the rational design of new CEACAM5-targeting therapies.

Anand Kumar
Francis Duffieux
Alexey Rak
ResearchOpen Access30 Oct 2024
Nature Communications

Volume: 15, P: 1-9
Filamentation of the bacterial bi-functional alcohol/aldehyde dehydrogenase AdhE is essential for substrate channeling and enzymatic regulation

Acetaldehyde–alcohol dehydrogenase (AdhE) converts acetyl-CoA to ethanol and is a key enzyme in bacterial alcoholic fermentation. AdhE forms spirosomes and, here, the authors present the cryoEM structures of compact and extended E.coli AdhE spirosomes and show that the extended conformation is the catalytically active form of the enzyme and discuss mechanistic implications.

Pauline Pony
Chiara Rapisarda
Rémi Fronzes
ResearchOpen Access18 Mar 2020
Nature Communications

Volume: 11, P: 1-11
Pilot clinical trial on supportive rehabilitation care in neonatal intensive unit. Influence of ambient noise on premature infants

Rita Chiaramonte
Matteo Cioni
Michele Vecchio
Research14 May 2025
Journal of Perinatology

Volume: 45, P: 1818-1819
A sustainable acoustic customization of open porous materials using recycled plastics

Marco Caniato
Luca Cozzarini
Andrea Gasparella
ResearchOpen Access29 Jun 2022
Scientific Reports

Volume: 12, P: 1-14
A clinical pilot study on the effect of the probiotic Lacticaseibacillus rhamnosus TOM 22.8 strain in women with vaginal dysbiosis

Alessandra Pino
Agnese Maria Chiara Rapisarda
Antonio Cianci
ResearchOpen Access28 Jan 2021
Scientific Reports

Volume: 11, P: 1-12
Optimal self-assembly of lipid nanoparticles (LNP) in a ring micromixer

Manon Ripoll
Elian Martin
Pierre Wils
ResearchOpen Access08 Jun 2022
Scientific Reports

Volume: 12, P: 1-12
Changes in gut microbiota in the acute phase after spinal cord injury correlate with severity of the lesion

Gabriele Bazzocchi
Silvia Turroni
Carlotte Kiekens
ResearchOpen Access17 Jun 2021
Scientific Reports

Volume: 11, P: 1-13

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Biogenesis and structure of a type VI secretion baseplate

Bacterial RadA is a DnaB-type helicase interacting with RecA to promote bidirectional D-loop extension

Structural insights into epitope-paratope interactions of a monoclonal antibody targeting CEACAM5-expressing tumors

Filamentation of the bacterial bi-functional alcohol/aldehyde dehydrogenase AdhE is essential for substrate channeling and enzymatic regulation

Pilot clinical trial on supportive rehabilitation care in neonatal intensive unit. Influence of ambient noise on premature infants

A sustainable acoustic customization of open porous materials using recycled plastics

A clinical pilot study on the effect of the probiotic Lacticaseibacillus rhamnosus TOM 22.8 strain in women with vaginal dysbiosis

Optimal self-assembly of lipid nanoparticles (LNP) in a ring micromixer

Changes in gut microbiota in the acute phase after spinal cord injury correlate with severity of the lesion

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