Nature Search

Prime editing of the β₁ adrenoceptor in the brain restores physiological REM sleep in a mouse model of Alzheimer’s disease

This study finds that prime editing of Adrb1^A187V in the mouse brain boosts excitability of β1- adrenergic neurons, wake behaviors, and memory, while lowering sleep pressure. In an Alzheimer’s model, Adrb1^A187V also restored physiological REM sleep amounts.

Desirée Böck
Lisa Tidecks
Gerald Schwank
ResearchOpen Access09 Dec 2025
Nature Communications

Volume: 16, P: 1-17
Body weight trajectories from midlife are associated with cognitive decline in advanced age

Chiara Ceolin
Federica Prinelli
Dorothee Volkert
ResearchOpen Access06 Jul 2025
Scientific Reports

Volume: 15, P: 1-15
Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes

Arrayed CRISPR libraries with each plasmid encoding an array of four non-overlapping single-guide RNAs allow for the efficient genome-wide ablation, activation and epigenetic silencing of human protein-coding genes.

Jiang-An Yin
Lukas Frick
Adriano Aguzzi
ResearchOpen Access04 Dec 2024
Nature Biomedical Engineering

Volume: 9, P: 127-148
Orthostatic hypotension and night-time dipper patterns in geriatric outpatients

Orthostatic and nocturnal changes in systolic blood pressure are inversely associated in older adults, probably due to aging-related autonomic nervous system deficits.

Lavinia M. A. Patetta
Alessandro Reffo
Giuseppe Sergi
Research09 Jun 2022
Hypertension Research

Volume: 45, P: 1468-1475
Factors influencing long-term persistence of anti-HBs after hepatitis B vaccination

Marco Fonzo
Chiara Bertoncello
Andrea Trevisan
ResearchOpen Access26 Dec 2022
npj Vaccines

Volume: 7, P: 1-7
Single-nucleotide polymorphisms in DNMT3B gene and DNMT3B mRNA expression in association with prostate cancer mortality

Renata Zelic
Valentina Fiano
Lorenzo Richiardi
Research19 Oct 2018
Prostate Cancer and Prostatic Diseases

Volume: 22, P: 284-291
Unraveling the role of GBA1 genotype in axial signs response to subthalamic deep brain stimulation

Francesco Bove
Danilo Genovese
L. Sambati
ResearchOpen Access17 Oct 2025
npj Parkinson's Disease

Volume: 11, P: 1-8
Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT2

Kathi Ging
Lukas Frick
Adriano Aguzzi
ResearchOpen Access22 Oct 2024
npj Parkinson's Disease

Volume: 10, P: 1-18
Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3α/β and Bax, leading to permeability transition pore opening and tumor cell death

F Chiara
A Gambalunga
A Trevisan
ResearchOpen Access13 Dec 2012
Cell Death & Disease

Volume: 3, P: e444
Self-sampling to increase participation in cervical cancer screening: an RCT comparing home mailing, distribution in pharmacies, and recall letter

P Giorgi Rossi
C Fortunato
Sara Boveri
ResearchOpen Access29 Jan 2015
British Journal of Cancer

Volume: 112, P: 667-675

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Prime editing of the β₁ adrenoceptor in the brain restores physiological REM sleep in a mouse model of Alzheimer’s disease

Body weight trajectories from midlife are associated with cognitive decline in advanced age

Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes

Orthostatic hypotension and night-time dipper patterns in geriatric outpatients

Factors influencing long-term persistence of anti-HBs after hepatitis B vaccination

Single-nucleotide polymorphisms in DNMT3B gene and DNMT3B mRNA expression in association with prostate cancer mortality

Unraveling the role of GBA1 genotype in axial signs response to subthalamic deep brain stimulation

Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT2

Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3α/β and Bax, leading to permeability transition pore opening and tumor cell death

Self-sampling to increase participation in cervical cancer screening: an RCT comparing home mailing, distribution in pharmacies, and recall letter

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