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Showing 1–3 of 3 results
Advanced filters: Author: Chien-Ping Yen Clear advanced filters

  • The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

    • Hung-Hsin Chen
    • Chien-Hsiun Chen
    • Cathy S. J. Fann
    ResearchOpen Access
    Nature
    Volume: 648, P: 128-137

  • Here the authors show TERRA R-loops recruit the endonuclease XPF to telomeres, leading to DNA double-strand breaks to activate break-induced telomere synthesis at telomeres that utilize the alternative lengthening of telomeres (ALT) pathway to extend their telomeres independent of telomerase.

    • Chia-Yu Guh
    • Hong-Jhih Shen
    • Hsueh-Ping Catherine Chu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19