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Showing 1–3 of 3 results
Advanced filters: Author: Chih-Ta Chien Clear advanced filters

  • CLC transporters exchange Cl− for H− with 2:1 stoichiometry. Here, authors integrate hydrogen-deuterium exchange, cryo-EM, MD simulations, ion binding analysis, and functional assays to establish a complete ion-exchange model, explaining how subtle dynamics enable reversible transport.

    • Deniz Aydin
    • Chih-Ta Chien
    • Merritt Maduke
    ResearchOpen Access
    Nature Communications
    P: 1-15

  • Single-particle cryo-EM, aided by simulations, of closed and open hub structures of the calcium calmodulin-dependent protein kinase II shows that the intrinsic hub polymorphism, conserved across isoforms, is due to dimer subunit exchange.

    • Chih-Ta Chien
    • Henry Puhl
    • Shahid Khan
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-13