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Showing 1–6 of 6 results
Advanced filters: Author: Chii Jou Chan Clear advanced filters

  • To celebrate the journal’s 25th anniversary, we asked 13 researchers to offer a glimpse of what their research field might look like in 2050. They consider how technological breakthroughs — for example, artificial intelligence-powered virtual cells — could transform our understanding of how molecules, organelles and cells behave in different contexts, revolutionize therapies and enable the design of resilient crops.

    • Monther Abu-Remaileh
    • Chii Jou Chan
    • Jan J. Żylicz
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 26, P: 735-740

  • Maturation of functional eggs in mammalian follicles is crucial for ovarian physiology. Here, Biswas et al. report that compressive stress by contractile theca cells or extrinsic perturbations can impact overall follicle mechanics, somatic cell signalling and functional growth of follicles, revealing insights into follicle mechanosensing and biophysical control of ovarian biology.

    • Arikta Biswas
    • Yuting Lou
    • Chii Jou Chan
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • A mouse blastocyst model reveals how lumenal pressure, cell cortical tension and tissue stiffness act at the tissue scale to regulate embryo size, which in turn influences the division pattern of trophectoderm cells and their fate specification.

    • Chii Jou Chan
    • Maria Costanzo
    • Takashi Hiiragi
    Research
    Nature
    Volume: 571, P: 112-116

  • Chan et al. apply Brillouin microscopy to study changes in tissue material properties during mammalian follicle development. Focusing on the Brillouin loss tangent which is independent of the refractive index and mass density, they find that mammalian folliculogenesis is characterised by region-specific changes in tissue micro-viscosity driven by cell differentiation and extracellular matrix remodelling.

    • Chii Jou Chan
    • Carlo Bevilacqua
    • Robert Prevedel
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-10