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Showing 1–12 of 12 results
Advanced filters: Author: Chirag R. Parikh Clear advanced filters

  • Cardiac surgery often requires the use of cardiopulmonary bypass, which can cause an inflammatory cascade that results in acute kidney injury (AKI). A recent post hoc analysis of a placebo-controlled, randomized trial suggests that intraoperative steroids might lower the risk of renal replacement therapy for AKI after cardiac surgery.

    • Chirag R. Parikh
    • Jennifer A. Schaub
    News & Views
    Nature Reviews Nephrology
    Volume: 11, P: 509-510

  • Comprehensive integration of gene expression with epigenetic features is needed to understand the transition of kidney cells from health to injury. Here, the authors integrate dual single nucleus RNA expression and chromatin accessibility, DNA methylation, and histone modifications to decipher the chromatin landscape of the kidney in reference and adaptive injury cell states, identifying a transcription factor network of ELF3, KLF6, and KLF10 which regulates adaptive repair and maladaptive failed repair.

    • Debora L. Gisch
    • Michelle Brennan
    • Michael T. Eadon
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • A high-resolution kidney cellular atlas of 51 main cell types, including rare and previously undescribed cell populations, represents a comprehensive benchmark of cellular states, neighbourhoods, outcome-associated signatures and publicly available interactive visualizations.

    • Blue B. Lake
    • Rajasree Menon
    • Sanjay Jain
    ResearchOpen Access
    Nature
    Volume: 619, P: 585-594

  • Prerenal azotemia is a common occurrence in hospitalized patients and is generally easier to define in clinical practice than in clinical research. Monitoring the duration of acute kidney injury and biomarkers of kidney function might help distinguish prerenal azotemia from acute tubular necrosis in both clinical practice and research settings.

    • Chirag R. Parikh
    • Steven G. Coca
    News & Views
    Nature Reviews Nephrology
    Volume: 6, P: 641-642

  • Kidney involvement is common in patients with acute SARS-CoV-2 infection, and subclinical inflammation and injury may persist for many months, resulting in a progressive decline in kidney function that leads to chronic kidney disease. Continued research is imperative to understand these long-term sequelae and identify interventions to mitigate them.

    • Sachin Yende
    • Chirag R. Parikh
    Comments & Opinion
    Nature Reviews Nephrology
    Volume: 17, P: 792-793

  • In this Review, the authors summarize the challenges associated with the care of patients with kidney disease during the COVID-19 pandemic. They describe the major challenges and missed opportunities, global inequalities in health care, and offer a framework for future pandemic preparedness.

    • Duvuru Geetha
    • Andreas Kronbichler
    • Valerie Luyckx
    Reviews
    Nature Reviews Nephrology
    Volume: 18, P: 724-737

  • Tissue cytometry is a promising new microscopy technique that can be used to enumerate and characterize each cell in a tissue. Here the authors describe a complete and accessible pipeline, including methods of sample preparation, microscopy, image analysis, and data analysis for large-scale three-dimensional tissue cytometry of human kidney tissues.

    • Michael J. Ferkowicz
    • Seth Winfree
    • Francis Perry Wilson
    Research
    Laboratory Investigation
    Volume: 101, P: 661-676