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Showing 1–2 of 2 results
Advanced filters: Author: Chloé Quignot Clear advanced filters

  • Dedifferentiated liposarcomas (DDLPS) typically have dedifferentiated (DD) and well-differentiated (WD) components, although their cellular origins remain elusive. Here, the authors characterise primary DDLPS tumours using bulk and single-cell multi-omics and find adipocyte stem cells that could be a common ancestor of WD and DD components.

    • Nadège Gruel
    • Chloé Quignot
    • Sarah Watson
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • During tumorigenesis, liposarcoma has been reported to develop a dependence on serine metabolism but it is unclear how this high energetic demand is met. Here, the authors identify a crosstalk mechanism between tumor and distant muscle cells wherein liposarcoma cell-derived IL-6 drives muscle cell release of serine, in turn accelerating tumor growth.

    • Gabrielle Manteaux
    • Alix Amsel
    • Laetitia K. Linares
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15